The Stroke Prevention Trial in Sickle Cell Anemia (STOP) was a randomized multicenter controlled trial comparing prophylactic blood transfusion with standard care in sickle cell anemia (SCA) children aged 2 to 16 years selected for high stroke risk by transcranial Doppler (TCD). More than 2000 children were screened with TCD to identify the 130 high-risk children who entered the randomized tria...

In this paper, we propose a new minimum total communication distance (TCD) algorithm and an optimal TCD algorithm for broadcast in a 2-dimension mesh. The former generates a minimum TCD from a given source node, and the latter guarantees a minimum TCD among all the possible source nodes. These algorithms can be generalized to a d-dimensional mesh or torus. TCD can potentially be used as a measu...

BACKGROUND For patients with cryptogenic stroke (CS) and patent foramen ovale (PFO), it is unknown whether the magnitude of right-to-left shunt (RLSh) measured by contrast transcranial Doppler (c-TCD) is correlated with the likelihood an identified PFO is related to CS as determined by the Risk of Paradoxical Embolism (RoPE) score. Additionally, for patients with CS, it is unknown whether PFO a...

OBJECTIVE To study the relationship and changes of cervical MRI, TCD and BAEP in patients with "isolated" vertigo. METHODS The relationship and changes of cervical MRI, TCD and BAEP were investigated respectively in 125 patients with "isolated" vertigo and 100 healthy controls. RESULTS There were statistically significant differences between two groups for overall abnormalities of TCD (X(2)...

Date: 1,2 December 2010 Venue: UCD Conway Institute Lecture Theatre Wednesday, 1 December (09:30–16:20) Session Chair: Dr Shane Duggan, TCD 0930 RNA detection and quantitation Dr Shane Duggan, TCD 1010 Differential gene expression: overview of relevant methods Dr Karen Power, UCD 1050 Coffee/Tea 1120 Polymorphism association with disease Prof. Denis Shields, UCD 1200 Model organisms Dr Alison R...

OBJECTIVE To assess contrast transcranial Doppler (TCD) for detection of right-to-left shunt (RLSh). METHODS We studied 30 patients aged between 25-45 years admitted to Al-Zahra Hospital, affiliated to Isfahan University of Medical Sciences, between May 2003 and May 2005. All patients underwent transesophageal echocardiography (TEE) with contrast and contrast TCD. RESULTS Eleven (36.6%) pat...

Hydroxyurea has hematologic and clinical efficacy in sickle cell anemia (SCA), but its effects on transcranial Doppler (TCD) flow velocities remain undefined. Fifty-nine children initiating hydroxyurea therapy for clinical severity had pretreatment baseline TCD measurements; 37 with increased flow velocities (> or = 140 cm/s) were then enrolled in an institutional review board (IRB)-approved pr...

Stroke, a devastating complication of sickle cell anemia (SCA), can cause irreversible brain injury with physical and cognitive deficits. Transcranial Doppler ultrasonography (TCD) is a non-invasive tool for identifying children with SCA at highest risk of stroke. National guidelines recommend that TCD screening begin at age 2 years, yet there is research to suggest less than half of young chil...

OBJECTIVE To compare the predictive accuracy of foetal trans-cerebellar diameter (TCD) with those of other biometric parameters in the estimation of gestational age (GA). DESIGN A cross-sectional study. SETTING The University of Benin Teaching Hospital, Nigeria. SUBJECTS Four hundred and fifty healthy singleton pregnant women, between 14-42 weeks gestation. MAIN OUTCOME MEASURES Trans-c...