successful application of a tbm in a project requires investigating both the ground conditions and the machine and backup system design features. prediction of the machine performance is very important as it has a big effect on the duration of the project and the costs. in this respect, both penetration rate and advance rate must be estimated. utilization factor, which depends on the type of op...

Successful application of a TBM in a project requires investigating both the ground conditions and the machine and backup system design features. Prediction of the machine performance is very important as it has a big effect on the duration of the project and the costs. In this respect, both penetration rate and advance rate must be estimated. Utilization factor, which depends on the type of op...

The study of downtime and subsequently machine utilization in a given project is one of the major requirements of an accurate estimation of TBM performance and daily advance rate. Interestingly, while it is very common to report the components of downtime when discussing a tunneling project in the literature; there has not been a great amount of in-depth studies on this topic in the recent year...

BACKGROUND Tuberculosis immune reconstitution inflammatory syndrome (IRIS) is a common cause of deterioration in human immunodeficiency virus (HIV)-infected patients receiving tuberculosis treatment after starting antiretroviral therapy (ART). Potentially life-threatening neurological involvement occurs frequently and has been suggested as a reason to defer ART. METHODS We conducted a prospec...

• Potential for AI techniques to detect clayey clogging in pipejacking is explored. Data decomposition into feature-based sub-series accentuates their features. The use of slurry density, torque and speed can be useful detecting clogging. ‘Clogging’ a common issue encountered during tunnelling soils which impede tunnel excavation, cause unplanned downtimes lead significant additional project co...

BACKGROUND The immunopathogenesis of tuberculosis-associated immune reconstitution inflammatory syndrome (IRIS) remains incompletely understood, and we know of only 1 disease site-specific study of the underlying immunology; we recently showed that Mycobacterium tuberculosis culture positivity and increased neutrophils in the cerebrospinal fluid (CSF) of patients with tuberculous meningitis (TB...

BACKGROUND Diagnosis of tuberculous meningitis (TBM) is difficult. Rapid confirmatory diagnosis is essential to initiate required therapy. There are very few published reports about the diagnostic significance of 65 kD heat shock protein (hsp) in TBM patients, which is present in a wide range of Mycobacterium tuberculosis species and elicits a cellular and humoral immune response. In the presen...

Tingible body macrophages (TBM), long thought simply as scavengers of apoptotic lymphocytes, are located in the unique microenvironment of germinal centers in close proximity to antigen-retaining follicular dendritic cells (FDC). Observations that TBM endocytose FDC-iccosomal (immune-complex coated bodies) antigen suggested that TBM might present this antigen and help regulate the germinal cent...

The present study was designed to investigate Rv2623 antigen, a major dormancy regulon protein of Mycobacterium tuberculosis (MTB) in CSF of suspected latent and active tuberculous meningitis (TBM) patients. A total of 100 CSF samples from TBM (n = 31), suspected latent TBM (n = 22), and suitable noninfectious control subjects (n = 47) were collected and evaluated for Rv2623 antigen level using...

Modified Levinson's precipitation test was done in 64 cases of TBM, 54 cases of TBM with inconsistent CSF finding, and 32 cases of pyogenic meningitis. The test was positive in 93.7% cases of TBM (sensitivity, 93.7%), 85.5% cases of TBM with doubtful diagnosis and in 9.4% cases of pyogenic meningitis (specificity 90.6%) compared to 79.7%, 72.2% and 18.8% in original Levinson's test, respectivel...