Paclitaxel and docetaxel are among the most widely used chemotherapeutic drugs against various types of cancer. However, these drugs cause undesirable side effects as well as drug resistance. Therefore, it is essential to develop next-generation taxoid anticancer agents with better pharmacological properties and improved activity especially against drug-resistant and metastatic cancers. The SAR...

Introduction: Taxoids, groups of diterpenoid cyclodecanes isolated from the genus Taxus, are known and used as anticancer agents. Starting from the successful results obtained by an original molecular descriptors family on structure-activity relationships (Jäntschi and Bolboacă, 2007), the aim of the research was to investigate and to assess the estimation and prediction abilities of this appro...

Two new taxoids called 7,13-dideacetyl-9,10-debenzoyl-7beta,9alpha-p-hydroxylbenzylidenedioxy-taxchinin C (1) and 7,13-dideacetyl-2,9,10-debenzoyl-2-tigloyl-7beta,9alpha-p-hydroxylbenzylidenedioxy-taxchinin C (2) were isolated from the leaves and stems of Taxus chinensis. They represent the first examples of taxoids containing the 5/7/6-membered ring system with 7beta,9alpha-p-hydroxylbenzylide...

background: taxus species are important due to their content of taxol, baccatin iii, 10- deacetyl baccatin and other taxoids suitable to change to active pharmaceutical ingredients, which are used as anti-neoplastic agents. investigations on taxoids carried out during the past four decades, resulted in identification of more than 350 taxoids. objective: this study aimed to isolate and identify ...

The applicability of a new mass spectrometric technique, DART (direct analysis in real time) has been studied in the analysis of the calli of Taxus wallichiana. The intact callus samples were directly analyzed by holding them in the gap between the DART source and mass spectrometer for measurements. Five C-14 oxygenated taxoids were characterized from the analysis of the calli of the Taxus wall...

The antitumor activity of newly developed taxoids possessing a sugar moiety (glucose, galactose or mannose) to improve water solubility was evaluated. Galactose-bound taxoid (10-alpha-GAG-DT) proved superior to all other taxoids in both water solubility and antitumor activity. Therapeutic efficacy of 10-alpha-GAG-DT in terms of in vivo antitumor activity was found to be approximately equivalent...

  Background: There are eight Taxus species and two hybrids in the world and Taxus baccata L. (European yew) is the single representative in Iran. Until now, a large number of taxoids possessing different skeleton systems, as well as lignans, flavonoids, steroids and sugar derivatives have been isolated from various Taxus species. Taxoids are highly oxygenated diterpenes isolated from different...

Liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/ MS) and high-performance liquid chromatography (HPLC) methods have been used to identify and quantify the major taxoids from extracts of Taxus chinensis cell cultures. Chromatography was carried out on a reverse phase C18 column with isocratic-mode elution. By analytically comparing LC/ESI-MS/MS of the extracts w...

background: there are eight taxus species and two hybrids in the world and taxus baccata l. (european yew) is the single representative in iran. until now, a large number of taxoids possessing different skeleton systems, as well as lignans, flavonoids, steroids and sugar derivatives have been isolated from various taxus species. taxoids are highly oxygenated diterpenes isolated from different s...