The occurrence of sensitivity to tartrazine was examined in 51 patients with asthma and aspirin sensitivity. All patients underwent oral challenge tests with aspirin and tartrazine. Sensitivity to tartrazine was found in 16 i.e. 31.4% of tested asthmatics. The symptoms of sensitivity to tartrazine were similar to those of aspirin. Tolerance to tartrazine was induced in 5 aspirin and tartrazine ...

We have developed an ultrasensitive indirect competitive enzyme-linked immunosorbent assay for the determination of tartrazine. Two carboxylated analogues of tartrazine with different spacer lengths, and one derivative from commercial tartrazine after a little chemical modification, were synthesized as haptens in order to produce antibodies specific to tartrazine. The effect of sulfonic acid gr...

Tartrazine is an artificial azo dye commonly used in human food and pharmaceutical products. Since the last assessment carried out by the JECFA in 1964, many new studies have been conducted, some of which have incriminated tartrazine in food intolerance reactions. The aims of this work are to update the hazard characterization and to revaluate the safety of tartrazine. Our bibliographical revie...

Tartrazine is a food colour that activates the transcriptional function of the human oestrogen receptor alpha in an in vitro cell model. Since oestrogens are cholestatic, we hypothesised tartrazine will cause periportal injury to the liver in vivo. To test this hypothesis, tartrazine was initially administered systemically to mice resulting in a periportal recruitment of inflammatory cells, inc...

Tracheal smooth muscle obtained from ovalbumin-sensitized guinea pigs contracted with micromolar concentrations of tartrazine and indomethacin. The contractions were slightly reduced by clemastine, but were completely blocked by the SRS-A antagonist FPL 55712. Arylsulfatase B, which is an enzyme that inactivates SRS-A, also abolished the contractions induced by tartrazine. Contractions induced ...

The effect of tartrazine on prostaglandin production was evaluated in several in vitro systems in order to elucidate the interrelationship between aspirin-sensitive asthma and tartrazine. Unlike the nonsteroidal anti-inflammatory drugs, tartrazine did not inhibit cyclooxygenase activity in sheep seminal vesicles, guinea pig lung microsomes, and human platelets. Tartrazine had no effect on the a...

The current research aimed to determine the influence of different doses of exposure to tartrazine on levels of hyperactivity, anxiety, depression and anti-social behaviours in rats. Forty five weanling male Wistar rats were randomly assigned into 3 groups of 15, divided on 2 replicates and administered our treatment daily in drinking water at different concentrations; 0, 1% and 2.5% for a 16 w...

Allergy to tartrazine-containing psychotropic medication (especially antidepressants) had been reported. 20 patients of apparent allergy to tartrazine-containing alprazolam brands in 480 patients exposed to the dye are described. Rechallenge with non tartrazine-containing alprazolam brands did not produce the similar allergic reactions.

Tartrazine dye has been implicated in a variety of adverse reactions. There is a high correlation between aspirin sensitivity and tartrazine sensitivity but the reverse is exceedingly rare. Herewith is presented a case where repeated occult exposures to tartrazine yellow dye in a patient who could take aspirin with impunity was uncovered by a deduction. The ubiquitous nature and protean manifes...

Tartrazine is a synthetic organic azo dye widely used in food and pharmaceutical products. The current study aimed to evaluate the possible adverse effect of this coloring food additive on renal and hepatic structures and functions. Also, the genotoxic potential of tartrazine on white blood cells was investigated using comet assay. Twenty adult male Wistar rats were grouped into two groups of 1...