Tamoxifen is routinely used for treatment of Estrogen-positive breast carcinoma. Approximately, 50% of patients with metastatic cancer will develop resistance to Tamoxifen. In this research, Tamoxifen was combined with the anti-cancer compound Curcumin. Diblock nanopolymer was used to package the new formulation of Curcumin and Tamoxifen. Anti-cancer efficacy of the obtained compound was evalua...

Tamoxifen is routinely used for treatment of Estrogen-positive breast carcinoma. Approximately, 50% of patients with metastatic cancer will develop resistance to Tamoxifen. In this research, Tamoxifen was combined with the anti-cancer compound Curcumin. Diblock nanopolymer was used to package the new formulation of Curcumin and Tamoxifen. Anti-cancer efficacy of the obtained compound was evalua...

background and objective: tamoxifen is one of the selective estrogen receptor modulators that exerts estrogen / anti-estrogen effects in various tissues. this study was done to evaluate the effect of chronic administration of tamoxifen on spatial memory and passive avoidance task in adult male wistar rats. methods: in this experimental study, 48 adult male wistar rats were randomly divided into...

background: accumulation of triglycerides in the liver i.e. steatosis, is a well-known side-effect of tamoxifen administration to patients suffering from breast cancer. cichoriumintybus (chicory) is a plant used as traditional medicine for curing liver disorders. in this study, the effects of extract prepared from chicory roots on tamoxifen-induced liver steatosis and related biochemical factor...

studies on biomedical applications of nanoparticles are growing with a rapid pace. in medicine, nanoparticles may be the solution for multi-drug-resistance which is still a major drawback in chemotherapy of cancer. in the present study, we investigated the potential cytotoxic effect of silver nanoparticles (ag nps) and silver ions (ag+) in both parent and tamoxifen-resistant t47d cells in prese...

Tamoxifen is the drug of choice in the treatment of breast cancer.   Recent reports show an increased incidence of endometrial carcinoma in patients taking tamoxifen.   In this article, we report a case of malignant mixed mullerian tumor after tamoxifen use.

It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...

Background: Tamoxifen treatment induced cell death in the hippocampus formation of the prenatal and postnatal rat. The present study delineates the effect of tamoxifen on developing hippocampus in prenatal, postnatal and full term neonate rats received certain doses of the partial antagonist tamoxifen. Methods: After perfusion and fixation, the brains were removed and processed for light and e...