Transcription activator-like effector (TALE) proteins can be designed to bind virtually any DNA sequence. General guidelines for design of TALE DNA-binding domains suggest that the 5'-most base of the DNA sequence bound by the TALE (the N0 base) should be a thymine. We quantified the N0 requirement by analysis of the activities of TALE transcription factors (TALE-TF), TALE recombinases (TALE-R)...

In fact, Stella felt some resentment towards the challenge itself. It was not that she did not 'do creative’; it was more about her fear of unknown, the fear of losing the safety of routine the fear of change. She had read a few articles about resistance to change before and was able to recognise the tell-tale symptoms of resistance not to change per se, but rather to the uncertainties and pote...

At the tipping point, it is known that small incident can trigger dramatic societal shift. Getting early-warning signals for such changes are valuable to avoid detrimental outcomes such as riots or collapses of nations. However, it is notoriously hard to capture the processes of such transitions in the real-world. Here, we demonstrate the occurrence of a major shift in public opinion in the for...

Ever since the beginning of the 21st century, the fairy tale has not only become a staple of the small and silver screen around the globe, it has also migrated into new media, overwhelming audiences with imaginative and spectacular retellings along the way. Indeed, modern fairy-tale adaptations pervading contemporary popular culture drastically subvert, shatter, and alter the public’s understan...

An index for an r.e. class of languages (by definition) generates a sequence of grammars defining the class. An index for an indexed family of languages (by definition) generates a sequence of decision procedures defining the family. F. Stephan’s model of noisy data is employed, in which, roughly, correct data crops up infinitely often, and incorrect data only finitely often. Studied, then, is ...

Hearing someone refer to themselves in the third person may seem "wacky", but you may be surprised to learn that it can actually be pretty helpful to the person doing it. Some people find that speaking in third person improves their self-esteem, their ability to perform well under stress, to manage their emotions more favorably, and to think through complex situations in a more rational and cal...

Hearing someone refer to themselves in the third person may seem "wacky", but you may be surprised to learn that it can actually be pretty helpful to the person doing it. Some people find that speaking in third person improves their self-esteem, their ability to perform well under stress, to manage their emotions more favorably, and to think through complex situations in a more rational and cal...

Hearing someone refer to themselves in the third person may seem "wacky", but you may be surprised to learn that it can actually be pretty helpful to the person doing it. Some people find that speaking in third person improves their self-esteem, their ability to perform well under stress, to manage their emotions more favorably, and to think through complex situations in a more rational and cal...