Zearalenone T-2 toxin Table I. Mycotoxins currently of most concern never be fully understood since laboratory studies, where interacting variables are of necessity limited, can only approximate the infinite number of variables manifested in nature, e.g., the chemical composition of the commodity, the complex interactions of the microbial flora, oxygen availability, presence or absence of herbi...

the effects of chromium methionine supplementation on performance and serummetaboliteswere evaluated in broiler chickens.two experiments were conducted at22 oc, thermoneutral, (tn) and33±2 oc, heat stressed (hs) conditions. two hundred and eighty eight male broiler chicks (ross 308) were allocated to four treatments in a completely randomized design. treatments with 0 (control), 200, 400 or 800...

Thirty-six wild-caught woodchucks (Marmota monax) were charac terized according to sex, weight, trapping locality, liver pathology, and serum or hepatic markers of woodchuck hepatitis virus. Liver subcellular fractions were assayed for microsomal cytochromes P-450, aryl hydro carbon hydroxylase, glutathione, cytosolic enzymes involved in its metab olism (glutathione S-transferase, glutathione p...

Hepatocyte nodules, structures consistently seen in every model of liver carcinogenesis well before the first appearance of cancer, were examined with respect to some Phase I and Phase II components considered to be important in the metabolism of carcinogens and other xenobiotics. Phase I components are those related to the metabolism of xenobiotics and include microsomal cytochromes P-450 and ...

tabolites between parasite and host tissues, or may inactivate parasite enzyme systems. Two major features of the vertebrate immune response are apparently undeveloped in invertebrates, namely, specificity, the complementarity between an antibody-combining site and a particular antigenic determinant, and memory, the increased responsiveness to foreign material as a result of previous antigenic ...

Ecdysteroid, Immunoadsorption of Steroids, Antiserum Specificity Two ecdysteroid-specific antisera, anti-ecdysone-albumin and anti-20-hydroxyecdysone-albumin, were induced in rabbits. The properties of both antisera were tested with a large number of ecdysteroids. The former antiserum was unique in its ability to discriminate between the moulting hormones, ecdysone and 20-hydroxyecdysone, where...

The in vivo metabolism and DMA binding of benzo(a)pyrene (BP) was examined in male Sprague-Dawley rat. BP was ad ministered i.v. at dose levels of 1.0 and 10.0 /¿mol/kg. DNA samples from [3H]BP-treated rats were enzymatically digested to deoxyribonucleosides and analyzed by high-pressure liquid chromatography. Several chromatographically distinct nucleoside-bound adducts were observed in lung ...

Benzene, an important industrial chemical, is myelotoxic and leukemogenic in humans. It is metabolized by cytochrome P450 2E1 to various phenolic metabolites which accumulate in the bone marrow. Bone marrow contains high levels of myeloperoxidase which can catalyze the further metabolism of the phenolic metabolites to reactive free radical species. Redox cycling of these free radical species pr...

Uptake of the antitumor agents hexamethylmelamine and pentamethylmelamine by L5178Y lymphoblasts was studied using both theoretical and experimental approaches. Using the analysis of Lieb and Stein, it was predicted that, if these two drugs enter L51 78Y cells by simple diffusion, uptake would be essentially complete in less than 10 sec. Experimentally, up take of intact hexamethylmelamine and ...