The compression during tabletting is a complex and irreversible dynamic process and the study of it with instrumented tablet presses is beneficial for process and formulation optimization. The compaction and ejection cycle provides us suitable signals about the tabletting process. Instrumented presses used in tabletting research and development are normally equipped to measure punch force and d...

in this paper, differences in porosity, compressive strength and tablet- forming ability of carbamazepine crystals agglomerated under similar condition, but subjected to different drying temperatures are reported. the agglomerates were prepared by spherical crystallization method and thereafter dried without agitation at different temperature. an increased drying temperature did not affect the ...

This paper discusses our preliminary trials examining the particle size and particle shape of granules produced by different screw elements in a co-rotating twin-screw extruder. In general, conveying elements did not provide the necessary consolidation to allow large particles to grow in significant quantity, whereas the different mixing elements led to the large particles desired for tablettin...

Introduction Since the late 1950s and early 60’s, conventional calcium hydrogen phosphate has been widely used as the excipient for direct compression tabletting. However, the fi rst generation of calcium phosphates were hard and rough pillar-like crystals with crystal water, which often caused abrasiveness of punches and dies in tabletting. In addition, the crystal water could possibly be rele...

In this paper, we present a modified density-dependent Drucker-Prager Cap (DPC) model with a nonlinear elasticity law developed to describe the compaction behavior of pharmaceutical powders. The model is implemented in ABAQUS with a user subroutine. Using microcrystalline cellulose (MCC) Avicel PH101 as an example, the modified DPC model is calibrated and used for finite element simulations of ...