Objective(s): TSH suppression by Levothyroxine consumption is a mainstay of thyroid cancer treatment. Tablet-splitting is a worldwide approach in dose adjustment in patients. However, it is highly recommended to evaluate the validity of tablet splitting for each distinctive drug by clinical trials before routinely using tablet halves in clinical practice. In this study we compared the effect of...

No: 687 Health and Hygiene 329 EVALUATION OF THE IMPACT OF TABLET SPLITTING ON THE ACCURACY OF DRUG DOSING H.S. Sellahewa and H.M.D.R. Herath* Department of Pharmacy, Faculty of Allied Health Sciences, University of Peradeniya, Sri Lanka *[email protected] Tablet splitting is commonly used in pharmacy practice. There are many reasons to split tablets such as to get the prescribed dose, to ad...

Tablet splitting is an accepted practice for the administration of drugs for a variety of reasons, including dose adjustment, ease of swallowing and cost savings. The purpose of this study was to evaluate the physical properties of lisinopril tablets as a result of splitting the tablets either by hand or with a splitting device. The impact of the splitting technique of lisinopril (Zestril® tabl...

Pharmacists have been splitting scored tablets to individualize and titrate dosages since the end of the pill-rolling era. We have generally accepted that scored tablets may be evenly divided, resulting in 2 half-tablets containing one-half of the whole tablet strength. Slight powdering is unavoidable, but it is generally accepted that loss of a few molecules of active drug is not likely to be ...

BACKGROUND Newer atypical antipsychotics such as aripiprazole (Abilify, Otsuka) and lurasidone (Latuda, Sunovion) have favorable safety and efficacy profiles, but their use is limited by high cost. University Hospitals Richmond Medical Center initiated an antipsychotic tablet-splitting program in August 2015 to counter the costs based on the identical pricing structure of aripiprazole and luras...

OBJECTIVE To split several tablet products relevant to the Veterans Affairs (VA) Maryland Healthcare System and assess whether the resulting half tablets provide equal doses. METHODS From a VA list of products that are required to be split, 7 products were evaluated, along with 5 other commonly split tablet products. A trained pharmacy student split tablets using a tablet splitter provided by...

BACKGROUND The price per milligram for most statin medications decreases at higher strengths, which provides an economic incentive to split tablets. We sought to determine the frequency with which statin tablets are split, and to evaluate factors associated with this practice. METHODS We obtained prescription claims data for statins from the BC Ministry of Health for the period Jan. 1, 1996, ...

OBJECTIVE The primary objective was to determine the effect of a hydroxymethylglutaryl- CoA reductase inhibitor (HMG) tablet-splitting program on laboratory outcomes (lipid panel and liver enzyme tests). Other objectives were to assess patient compliance and satisfaction with splitting tablets and to measure the reduction in drug acquisition costs. METHODS Patients at a Veterans Affairs Healt...