objective(s): t-cell acute lymphoblastic leukemia (t-all) is an aggressive hematologic malignant tumor. administration of chemical compounds influencing apoptosis and t cell development has been discussed as promising novel therapeutic strategies. valproic acid (vpa) as a recently emerged anti-neoplastic histone deacetylase (hdac) inhibitor and pioglitazone (pgz) as a high-affinity peroxisome p...

background: apart from genetic and environmental factors, activation of autoreactive mechanisms has been proposed to play a role in the pathogenesis of schizophrenia. in re-cent years, considerable work has been carried out to understand the role and contribution of the immune system in this disease. objective: to investigate the t cell response to phytohaemagglutinin (pha) and determine the se...

aerial parts of salvia mirzayanii was extracted with methanol. methanol extract was suspended in water and defatted with petroleum ether. the defatted part was then partitioned between ethyl acetate and water. the ethyl acetate partition was chromatographed on a silica gel column to afford several fractions. lymphocyte proliferation inhibitory assay of the resulted fractions was compared in vit...

back ground: candida albicans is a member of the normal human microflora. c. albicans cell wall is composed of several protein and carbohydrate components which have been shown to play a crucial role in c. albicans interaction with the host immune system. major components of c. albican cell wall are carbohydrates such as mannans, β glucans and chitins, and proteins that partially modulate the h...

introduction: cardiac glycosides such as digoxin or digitoxin are the natural products that are traditionally used to increase cardiac contractile force in patients with heart failure and cardiac arrhythmias. it has been shown that digoxin can directly inhibit the cell proliferation and lead to cell apoptosis. present study was conducted to analyze the effect of digoxin in the cohorts of mesenc...

the ethyl acetate partition of dried methanolic extract of aerial parts of euphorbia microsciadia (euphorbiaceae) afforded three pentacyclic triterpenes, betulinic acid (1) from lupane type, oleanolic acid (2) from oleane type and ursolic acid (3) from ursane type triterpenes that are reported for the first time in this plant. these three compounds were structurally compared through their mass ...

objectives : platelet preparations are commonly used to enhance bone and soft tissue regeneration. considering the existing controversies on the efficacy of platelet products for tissue regeneration, more in vitro studies are required. the aim of the present study was to compare the in vitro effects of plasma rich in growth factors (prgf) and platelet-rich fibrin (prf) on proliferation and viab...

Background: Progesterone is an endogenous immunomodulator that suppresses T cell activation during pregnancy. The stimulation of membrane progesterone receptors (mPRs) would seem to be the cause of rapid non-genomic responses in human peripheral T cells, such as an elevation of intracellular calcium ([Ca2+] i) and decreased intracellular pH (pHi). Mifepristoneimmune cells compared with progeste...

conclusions our data suggest that preconditioning with 5 μm h2o2 + 0.5% fbs and 10 μm h2o2 + 5% fbs improved cell proliferation and viability. however, the mechanisms related to protective properties of preconditioning and using this strategy in stem cell therapy requires more research. background mesenchymal stem cells (mscs) survival decreased following in vivo injection and its application h...