Background: Pulmonary tuberculosis (PTB) has recently become a major problem in developed countries especially in immune compromised HIV infected individuals. Cytokines, their genes and receptors have been implicated in the protective immunity, pathophysiology and development of tuberculosis.   Material & Methods: In the present study the genotype frequencies of a number of polymorphic genes co...

background: pulmonary tuberculosis (ptb) has recently become a major problem in developed countries especially in immune compromised hiv infected individuals. cytokines, their genes and receptors have been implicated in the protective immunity, pathophysiology and development of tuberculosis.   material & methods: in the present study the genotype frequencies of a number of polymorphic genes co...

background: the t allele of the hepatic lipase (hl) c-514t polymorphism was previously found to be associated with lower plasma hl activity. here, we examined the association between this polymorphism and plasma hdl-cholesterol concentrations in patients with coronary arteries stenosis. methods: we studied 342 subjects undergoing coronary angiography in two groups of non cad (n=146) and cad (n=...

strains of trichoderma harzianum s. l. have a great importance because of affecting mankind by being used as biological control agents against plant pathogens. in the present study, we planned to characterize the phylogenetic structure of t. harzianum recovered from different geographical origins and various habitats in some climates of iran (nc, scd, csw). in order to screen 239 collected tric...

Aim . To study the association of nucleotide polymorphisms in platelet receptor and cytochrome P450 genes with development resistance to antiplatelet drugs CHD patients. Material Methods The included 243 patients diagnosed after coronary artery bypass surgery (CABG), including 140 acetylsalicylic acid (ASA) treatment group 103 dual therapy (DAT) group. All were tested for aggregation using an o...

Objective(s): FOXP3 gene is an X-linked gene that encodes FOXP3 protein, an essential transcription factor in CD4+CD25+FOXP3+ regulatory T (Treg) cells.  We aimed, in the present study, to investigate the association of two FOXP3 polymorphisms, -2383 C/T (rs3761549) and IVS9+459 T/C (rs2280883), with lung cancer. Materials and Methods:  In a case-control study we analyzed genotypes and alleles ...

Background: Adiponectin, an adipocyte-secreted hormone, is known to have anti-atherogenic, anti-inflammatory, and anti-diabetic properties. In the present study, the association between two common single nucleotide polymorphisms (SNPs) (+45T/G and +276G/T) of ADIOPQ gene and coronary artery disease (CAD) was assessed in the subjects with type 2 diabetes (T2DM). Methods: Genotypes of two SNPs we...

Background and Aims: Several studies have shown that host genetic factors can be associated with the risk of developing Helicobacter pylori infections. Therefore, we evaluated the most prevalent toll-like receptors (TLRs) polymorphisms in Helicobacter pylori positive subjects and their possible role in susceptibility to Helicobacter pylori infections. Materials and Methods: Using related keywo...

The polymorphic variants of CYP1A1 and the deletion GSTM1 are present in Peruvian mestizo population. Wild type mutated genotypes (WT/*2A *2A/ *2A) were identified, whose allele frequencies 0.31 (T allele) 0.69 (C allele), respectively; 53% with wild (+) 47% null . frequency Iquiteño emigrants was 0.72 CYP1A1*2A 25% (-); from Lima 0.67 33% (-). Hardy-Weinberg equilibrium test for studied popula...