we present a 21-years old woman with alopecia universalis, generalized vitiligo, and graves' disease. she had had thyroidectomy in early childhood and was receiving replacement therapy with levothyroxine. the patient was treated with systemic puva and glucocorticoid in combination with topical treatment for alopecia. after 6 months of treatment, alopecia was reversed but vitiligo was unchanged.

Background and aim: Psoriasis is one of the most common inflammatory skin disorders with a genetic background. Several treatment modalities have been used, including systemic and bath PUVA. The aim of this study was to evaluate the efficacy of systemic and bath PUVA in the treatment of psoriasis in Razi Hospital.Materials and methods: This retrospective database study was done in Razi Hospital ...

INTRODUCTION Palmoplantar psoriasis is an uncommon clinical form of psoriasis. Although localized to the palms and soles, it has a considerable impact on the patient's function and quality of life. OBJECTIVES To study the effectiveness and safety of psoralen-UV-A (PUVA) therapy in palmoplantar psoriasis and investigate predictors of clinical response. MATERIAL AND METHODS We performed a ret...

Background: Vitiligo is a relatively common acquired depigmentary disorder affecting approximately 1% of general population. PUVA therapy is the most effective modality and commonly used as the primary treatment of generalized Vitiligo. Objective: To evaluate the synergistic effect of topical Calcipotriol and oral methoxalene plus PUVA in treatment of generalized Vitiligo. Patients and Me...

PUVA therapy is widely used for early stage mycosis fungoides. While the efficacy of PUVA with oral 8-methoxypsoralen (8-MOP) is well documented, the use of its topical variation, bath-water PUVA therapy with 8-MOP has not been studied. The purpose of this study was to assess the effect of 8-MOP bath-water PUVA therapy in adult patients with early stage mycosis fungoides. We retrospectively eva...

AIM To assess the efficacy of betamethasone dipropionate 0.05% cream plus ultraviolet B (UVB) radiation with and without additional penicillin therapy in the treatment of guttate psoriasis, and to compare the efficacies of oral psoralen plus ultraviolet A (PUVA) therapy and systemic retinoids therapy for treatment of generalized psoriasis. METHODS Sixty patients with guttate (n = 20) and gene...

BACKGROUND Photochemotherapy with 8-methoxypsoralen and long-wavelength UV-A (PUVA) has been extensively used for the treatment of various skin diseases since its approval in 1982 by the US Food and Drug Administration. METHODS A retrospective study was performed of patients treated with PUVA, including topical and systemic treatment, over a period of 14 years. All patients were treated using...

Background: Chronic graft versus host disease (ch.GVHD) is the most frequent late complication after allogenic stem-cell transplantation. Systemic immunosuppressive agents are usually required to control the disease. Psoralen plus UVA (PUVA) has been used for the treatment of ch.GVHD with variable beneficial effects. The objective of this study was to assess the efficacy and safety of a r...

Psoriasis is a cutaneous disease as well systemic chronic inflammatory that closely associated with multiple comorbidities, such cardiovascular diseases, diabetes, and metabolic syndrome. Recently developed treatment modalities are highly effective for psoriasis skin lesions. The greater the extent of body surface area affected, more prone patient to psoriatic arthritis inflammation. Therefore,...

The choice of tactics for managing a patient with mycosis fungoides is determined by the stage disease. In early stages fungoides, treatment approach using external therapy and various ultraviolet irradiation spectra (UVB-311 nm PUVA therapy) preferable. With insufficient efficiency / or short remissions in some patients, it possible to use combined methods stages: UVB-311 therapy. combination ...