statement of problem: the elimination of actinobacillus actinomycetemcomitans (a.a) is a key factor for achieving a successful treatment in patients with aggressive periodontitis (agp) whom harboring this organism. this micro organism’s capability to invade to host’s tissues, makes its eradication with mechanical therapy (eg. flap surgery, scaling, oral hygiene) very difficult, so there is no o...

systemic antibiotics in conjunction with scaling and root planing (srp), can offer an additional benefi t over srp alone in the treatment of periodontitis, in terms of clinical attachment loss (cal) and pocket depth change, and reduced risk of additional cal loss. however, antibiotics are not innocuous drugs. their use should be justifi ed on the basis of a clearly established need and should n...

Two stage total hip arthroplasty revision surgery includes foreign material debridment, insertion of antibiotic impregnatedcement spacer, and finally, reimplantation of the prosthesis. This review has aimed to evaluate the efficacy of antibioticimpregnated cement spacers in infection control and eradication in arthroplasties.A total of 85 articles on total hip arthroplasty wer...

OBJECTIVE To synthesise the available evidence and estimate the comparative efficacy of control strategies to prevent total hip replacement (THR)-related surgical site infections (SSIs) using a mixed treatment comparison. DESIGN Systematic review and mixed treatment comparison. SETTING Hospital and other healthcare settings. PARTICIPANTS Patients undergoing THR. PRIMARY AND SECONDARY OU...

Background The concept of using antibiotics to treat Scleroderma stems from research done initially by Thomas M Brown, MD at the National Institutes of Health, Johns Hopkins and the Rockefeller Institute. Brown used antibiotic therapy to treat a variety of autoimmune diseases based on the theory that arthritic diseases, including Scleroderma, are caused by mycoplasma or bacterial infections. My...

Local antibiotic delivery with antibiotic loaded acrylic bone cement has been used extensively in the management of chronic osteomyelitis and implant related infections. It is considered the gold standard for treatment of musculoskeletal infections (Nelson, 2004; Hanssen, 2005; Samuel et al., 2010). The critical factors in the treatment of any orthopaedic infection are adequate surgical debride...

To date, several strategies have been developed to provide local antibiotic therapy in the treatment of osteomyelitis, such as antibiotic-loaded bone cement, antibiotic-impregnated collagen sponges, polymethylmethacrylate beads, antibiotic-loaded bone graft, antibiotic-loaded synthetic bone substitutes, and antibiotic-coated implants. The optimum carrier for local antibiotic therapy has not bee...

This study determined the trends in the quantities and patterns of nationwide antibiotic consumption in the Republic of Korea (ROK).This nationwide descriptive epidemiological study was conducted in the ROK between 2008 and 2012. The quantities and patterns of total systemic antibiotic prescriptions were analyzed using National Health Insurance claims data collected through the Health Insurance...