BACKGROUND Postpartum hemorrhage is a significant cause of maternal mortality and morbidity, worldwide. OBJECTIVES The aim of this study was to compare the efficacy between carbetocin and syntometrine in prevention of postpartum hemorrhage. MATERIALS AND METHODS This study was a double blind randomized clinical trial that carried out on 200 pregnant women referred to Shabiehkhani maternity c...

OBJECTIVES a) To compare the clinical effect of rectal misoprostol with intramuscular syntometrine in reducing blood loss in the third stage of labour b) to determine the severity and incidence of side effects of both drugs and c) to measure blood loss, patient tolerance and acceptance of rectal misoprostol. METHODS One hundred and forty parturients were randomly allocated to receive intramus...

OBJECTIVE Syntometrine is an effective uterotonic agent used in preventing primary postpartum haemorrhage but has adverse effects including nausea, vomiting, hypertension and coronary artery spasm. Carbetocin is a newly developed long-acting oxytocin analogue that might be used as an uterotonic agent. We compare the efficacy and safety of intramuscular (IM) carbetocin with IM syntometrine in pr...

The aim was to assess the efficacy of Syntometrine ® (500 micrograms ergometrine with 5 units oxytocin) as an appropriate alternative first-line uterotonic for use in elective caesarean section (CS) during a national shortage of UK-licensed IV oxytocin from April-June 2014. An observational study was performed involving 2 groups of 22 women undergoing elective CS in a UK DGH during this period....

background postpartum hemorrhage is a significant cause of maternal mortality and morbidity, worldwide. objectives the aim of this study was to compare the efficacy between carbetocin and syntometrine in prevention of postpartum hemorrhage. materials and methods this study was a double blind randomized clinical trial that carried out on 200 pregnant women referred to shabiehkhani maternity cente...

Objective To compare intramuscular oxytocin, Syntometrine® and carbetocin for prevention of postpartum haemorrhage after vaginal birth. Design Randomised double-blinded clinical trial. Setting Six hospitals in England. Population A total 5929 normotensive women having a singleton Methods Randomisation when birth was imminent. Main outcome measures Primary: use additional uterotonic agents. Seco...

The clinical course is described of an infant who accidentally received an adult dose of Syntometrine (synthetic oxytocin + ergometrine) at delivery. The infant soon became ill with convulsions and ventilatory failure, and later with water intoxication. Similar reported cases are reviewed and recommendations are given for the management of future cases.

Postpartum haemorrhage is the leading cause of maternal mortality worldwide: 67-80% of cases are caused by uterine atony. Preventive measures include prophylactic drug use to aid uterine contraction after delivery, thus avoiding severe blood loss and reducing maternal morbidity and mortality. Carbetocin is a synthetic analogue of oxytocin with a half-life approximately 4-10 times longer than th...