نتایج جستجو برای: sy5y cells

تعداد نتایج: 1383827  

Background and purpose: Recent studies have demonstrated the promising effects of mesenchymal stem cells (MSCs) in some neurodegenerative diseases and proved their neuroprotective effects. But, the detailed pathways and the ability of MSCs from various sources has not been fully investigated. Materials and methods: Here, we isolated MSCs from two sources; adipose tissue and dental pulp, and co...

Journal: :research journal of pharmacognosy 2015
m. a. esmaeili m. alilou a. sonboli

background and objectives: oxidative stress is implicated in the neuronal damage associated with alzheimer’s disease, parkinson’s disease, huntington’s disease, amyotropic lateral sclerosis and cerebral ischemic stroke. the present work was designed to establish the neuroprotective effects of salvia aristata extract on h2o2-induced apoptosis in human dopaminergic sh-sy5y cells. methods: the tot...

Background and Objective: Alzheimer’s disease (AD) is a neurodegenerative disorder which is associated with extracellular accumulation of amyloid beta (Aβ) plaques. AD is accompanied by mitochondrial dysfunction and energy metabolism reduction. Fibroblast growth factor 21 (FGF21) is an endogenous polypeptide which its beneficial effects have been demonstrated on mitochondrial function, energy m...

A. Sonboli M. A. Esmaeili M. Alilou

Background and objectives: Oxidative stress is implicated in the neuronal damage associated with Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotropic lateral sclerosis and cerebral ischemic stroke. The present work was designed to establish the neuroprotective effects of Salvia aristata extract on H2O2-induced apoptosis in human dopaminergic ...

Journal: :Journal of advances in medical and biomedical research 2022

Rheum turkestanicum Janisch Root Extract Mitigates 6-OHDA-Induced Neuronal Toxicity Against Human Neuroblastoma SH-SY5Y Cells

Journal: :Cumhuriyet medical journal 2023

Objective: This study aimed to assess the enhanced anticancer effect of Temozolomide (TMZ) through a synergistic combination with Diltiazem (DTZ) in neuroblastoma cell line (SH-SY5Y).
 Material and Methods: The SH-SY5Y was cultured DMEM medium. TMZ DTZ stock solutions were prepared diluted obtain different concentrations. XTT assay performed evaluate viability. Cells treated alone or for 2...

Journal: :Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2001
A Edsjö B Hallberg S Fagerström C Larsson H Axelson S Påhlman

Despite their sympathetic neuroblast origin, highly malignant neuroblastoma tumors and derived cell lines have no or low expression of the neurotrophin receptor genes, trkA and trkC. Expression of exogenous trkA in neuroblastoma cells restores their ability to differentiate in response to nerve growth factor (NGF). Here we show that stable expression of trkC in SH-SY5Y neuroblastoma cells resul...

Journal: :Anticancer Research 2021

Background/Aim: We have previously reported the identification of cytotoxic chemotype compound-I (CC-I) from a chemical library screening against glioblastoma. Materials and Methods: The biological activity CC-I on drug-resistant neuroblastomas [e.g., HFE gene variant C282Y stably transfected human neuroblastoma SH-SY5Y cells (C282Y HFE/SH-SY5Y), SK-N-AS] was characterized using cell culture mo...

2012
Yan Li Hua Xiong Da-Qing Yang

Ataxia-telangiectasia (A-T) is an autosomal recessive disorder characterized by cerebellar ataxia and oculocutaneous telangiectasias. The gene mutated in this disease, ATM (A-T, mutated), encodes a 370-kDa Ser/Thr protein kinase. ATM not only mediates cellular response to DNA damage but also acts as an activator of Akt in response to insulin. However, despite intensive studies, the mechanism...

Journal: :مجله علوم اعصاب شفای خاتم 0
somaye heidari pharmaceutical research center, faculty of pharmacy, mashhad university of medical sciences, mashhad, iran hossein hosseinzadeh pharmaceutical research center, faculty of pharmacy, mashhad university of medical sciences, mashhad, iran soghra mehri pharmaceutical research center, faculty of pharmacy, mashhad university of medical sciences, mashhad, iran

introduction: d-galactose (d-gal) is well known as an appropriate agent to induced aging effects in the in vivo and in vitro models. in the present study, we selected crocin, the main constituent of crocus sativus l. (saffron), against d-gal cytotoxicity in human neuroblastoma sh-sy5y cells. materials and methods:  cells were pretreated with crocin (25-500 µm) for 24 h and then exposed to d-gal...

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