AIMS We assessed regulation of volume-sensitive Cl(-) current (I(Cl,swell)) by endothelin-1 (ET-1) and characterized the signalling pathway responsible for its activation in rabbit atrial and ventricular myocytes. METHODS AND RESULTS ET-1 elicited I(Cl,swell) under isosmotic conditions. Outwardly rectified Cl(-) current was blocked by the I(Cl,swell)-selective inhibitor DCPIB or osmotic shrin...

In this investigation, three different swell systems known in pipe organs, the swell box, the crescendo wheel, and the historic wind swell were measured and compared to each other. The dynamic range of the crescendo wheel was found to be most effective, and for frequencies near 2 kHz the increase in sound pressure level could be up to 50 dB between the softest and the loudest adjustment. The ma...

Presence of swelling soils under the foundations of civil engineering structures particularly lightly loaded structures has caused serious damages around the globe due to their differential up heaving. In this paper, based on the results of swell tests on bentonite mixed clay, correlations for predicting the swelling parameters (i.e., swell potential and swell pressure) have been proposed. Mixi...

The role of swelling-activated currents in cell volume regulation is unclear. Currents elicited by swelling rabbit ventricular myocytes in solutions with 0.6-0.9x normal osmolarity were studied using amphotericin perforated patch clamp techniques, and cell volume was examined concurrently by digital video microscopy. Graded swelling caused graded activation of an inwardly rectifying, time-indep...

Extrudate swell is often observed to be weakened in nanocomposites compared to the pure polymer matrix. A theory quantifying this would be significant either for optimum processing or for understanding their viscoelasticity. A unified extrudate swell correlation with material properties and capillary parameters was suggested for polymer melt and their nanocomposites when considering the reservo...

When cells swell in hypo-osmotic solutions, chloride-selective ion channels (Cl(swell)) activate to reduce intracellular osmolality and prevent catastrophic cell rupture. Despite intensive efforts to assign a molecular identity to the mammalian Cl(swell) channel, it remains unknown. In an unbiased genome-wide RNA interference (RNAi) screen of Drosophila cells stably expressing an anion-sensitiv...

Regulation of swelling-activated Cl(-) current (I(Cl,swell)) is complex, and multiple signaling cascades are implicated. To determine whether protein tyrosine kinase (PTK) modulates I(Cl,swell) and to identify the PTK involved, we studied the effects of a broad-spectrum PTK inhibitor (genistein), selective inhibitors of Src (PP2, a pyrazolopyrimidine) and epidermal growth factor receptor (EGFR)...

[1] Field measurements of the ocean surface wave spectrum focusing on the slope-contributing components are used to construct a spectral model of the ocean surface roughness. The spectral parameterization is established with the observed empirical power law relation between the dimensionless wave spectral density and wind speed. The power law parameters (proportionality coefficient and exponent...

Using global satellite Synthetic Aperture Radar (SAR) observations, swell systems are confirmed to travel over very large distances across ocean basins. Satellite observations can provide a global view of swell systems when using a specific ”wave mode” sampling. The data are gathered globally and systematically, but the SAR-derived peak wavelength and directional parameters are restricted to th...