Epilepsy is a disease marked by hypersynchronous bursts of neuronal activity; therefore, identifying the network characteristics of the epileptic brain is important. Juvenile myoclonic epilepsy (JME) represents a common, idiopathic generalized epileptic syndrome, characterized by spike-and-wave discharge (SWD) electroencephalographic (EEG) waveforms. We compare herein the network properties of ...

Spike-and-wave discharge is an electroencephalographic brainwave found in many rodent species and studied rigorously in inbred laboratory rats (WAG/Rij and GAERS strains) for its similarities to absence epilepsy. The absence epilepsy research field, however, is divided on just how similar SWD in rats is to absence epilepsy in humans. Albino Sprague Dawley rats are an outbred strain used in many...

PURPOSE While decades of research were devoted to study generation mechanisms of spontaneous spike and wave discharges (SWD), little attention has been paid to network mechanisms associated with the spontaneous termination of SWD. In the current study coupling-dynamics at the onset and termination of SWD were studied in an extended part of the cortico-thalamo-cortical system of freely moving, g...

Epileptic activity in the form of spike-wave discharges (SWD) appears in the electroencephalogram (EEG) during absence seizures. A relationship between SWD and normal sleep spindles is often assumed. This study compares time-frequency parameters of SWD and sleep spindles as recorded in the EEG in the WAG/Rij rat model of absence epilepsy. Fast Fourier transformation and continuous wavelet trans...

Linear Granger causality was used to identify the coupling strength and directionality of information transport between frontal cortex and thalamus during spontaneous absence seizures in a genetic model, the WAG/Rij rats. Electroencephalograms were recorded at the cortical surface and from the specific thalamus. Granger coupling strength was measured before, during and after the occurrence of s...

BACKGROUND AND PURPOSE  Chronic pelvic inflammatory disease (PID) refers to both residue of acute and sub-acute recurrence of a previous infection or/and as a result of late detection of and intervention for upper tract pelvic infection. Owing to the chronic nature of the disease, which may require large doses of analgesics and/or antibiotics both of which may have side effects on the body, the...

We present a method for the detection of SWD in the cortical EEG of GAERS. The method is based on the key observation that SWD are pseudo-periodic signals. This harmonic structure can be revealed and successfully exploited by using the spectrogram. It is shown that for nine EEG-recordings of eight different GAERS, a maximum sensitivity and specificity of 94 percent can be achieved. Keywords—EEG...

The rhythms of spontaneously occurring seizures (spike-wave discharges, SWD) and motor activity, as well as the relationship between SWD and sleep-wake states were investigated in the WAG/Rij rat model of absence epilepsy. In order to establish whether SWD are controlled by external (Zeitgebers) or by endogenous factors such as circadian influences or the state of vigilance, the study was perfo...

A certain proportion of laboratory rats of various strains show spontaneous nonconvulsive ECoG seizures in the form of bursts of spike-and-wave discharges (SWD). Since in the majority of behavioural experiments the EEG is not controlled, the experimenter is usually unaware of this fact. The purpose of the present work was to find out whether the SWD trait is related to the rats behavioural perf...

BACKGROUND Stepped wedge design (SWD) is a cluster randomized controlled trial (RCT) design that sequentially rolls out intervention to all clusters at varying time points. Being a relatively new design method, reporting quality has yet to be explored, and this review will seek to fill this gap in knowledge. OBJECTIVES The objectives of this review are: 1) to assess the quality of SWD trial r...