نتایج جستجو برای: sustained virological responses

تعداد نتایج: 476190  

Journal: :iranian red crescent medical journal 0
mahtab daneshvar department of hepatitis and aids, pasteur institute of iran, tehran, ir iran; genetics department, zanjan branch, islamic azad university, zanjan, ir iran mehri nikbin iranian liver charity, tehran, ir iran solmaz talebi department of biostatistics and epidemiology, tehran university of medical sciences, tehran, ir iran foozieh javadi department of hepatitis and aids, pasteur institute of iran, tehran, ir iran mohammad reza aghasadeghi department of hepatitis and aids, pasteur institute of iran, tehran, ir iran sanaz mahmazi genetics department, zanjan branch, islamic azad university, zanjan, ir iran

results the analysis of data for c/t snp showed that the cc genotype is more common in the control group than in the group of patients. in contrast, the frequency of tt as a mutant genotype is more frequent in patients than in uninfected people. in addition, results showed a statistically significant relationship between cc, ct, and tt genotypes in sensitive and resistant groups (p value: < 0.0...

A. SHARIFI, A. GHAVIDEL, F. MANSOURGHANAEI, H. FOROOTAN, H. MIRMOMEN, H. VOSOGHINIA, H. GHOFRANI, M. AMIRIAN, M. AZMI, M. FARAHVASH, M. NASIRI, M. TALEBI, M. ZAHEDI, N. DARYANI, SH. MIRMOMEN,

 ABSTRACT Background: Combination therapy with interferon and ribavirin is the most effective treatment for chronic hepatitis C today. The aim of this study was to evaluate the efficacy and safety of thrice-weekly Heberon (interferon alfa-2b) in combination with ribavirin as first -line treatment of chronic hepatitis C. Methods: A total of97 treatment-naive patients received Heberon three milli...

Journal: :medical journal of islamic republic of iran 0
h. forootan digestive research centel; tehran university of medical sciences, imam khomeini hospital, tehran. a. sharifi digestive research centel; tehran university of medical sciences, imam khomeini hospital, tehran. sh. mirmomen digestive research centel; tehran university of medical sciences, imam khomeini hospital, tehran. n. daryani digestive research centel; tehran university of medical sciences, imam khomeini hospital, tehran. h. ghofrani digestive research centel; tehran university of medical sciences, imam khomeini hospital, tehran. m. farahvash digestive research centel; tehran university of medical sciences, imam khomeini hospital, tehran.

abstract background: combination therapy with interferon and ribavirin is the most effective treatment for chronic hepatitis c today. the aim of this study was to evaluate the efficacy and safety of thrice-weekly heberon (interferon alfa-2b) in combination with ribavirin as first -line treatment of chronic hepatitis c. methods: a total of97 treatment-naive patients received heberon three millio...

Journal: :hepatitis monthly 0
ya wen viral hepatitis key laboratary, department of infectious disease, xiangya hospital, central south university; changsha, china yi xiang zheng viral hepatitis key laboratary, department of infectious disease, xiangya hospital, central south university; changsha, china de ming tan viral hepatitis key laboratary, department of infectious disease, xiangya hospital, central south university; changsha, china; viral hepatitis key laboratary, department of infectious disease, xiangya hospital, central south university, changsha, china. tel: +86-13958868582, fax: +86-073189753766

results patients who attained sustained virological response had a less risk (85%) for all-cause mortality and about 63% reduced risk of hepatocellular carcinoma incidence than those who did not achieve sustained virological response. based on deeply analysis, the stage of liver fibrosis was a risk factor at baseline for the incidence of hepatocellular carcinoma. conclusions sustained virologic...

Journal: :hepatitis monthly 0
mahmoud a. khattab department of motmsoom,memk{oon oonoasu~owovw{}ogy and hepatology, minia university, p.o. box: 61111,, egypt +20-225197818;+20-862378181, [email protected]; department of motmsoom,memk{oon oonoasu~owovw{}ogy and hepatology, minia university, p.o. box: 61111,, egypt +20-225197818;+20-862378181, [email protected] mohammed eslam department of motmsoom,memk{oon oonoasu~owovw{}ogy and hepatology, minia university, p.o. box: 61111,, egypt +20-225197818;+20-862378181, [email protected] michele malaguarnera department of biochemistry, medical chemistry and molecular biology, university of catania, italy maria giordano department of biochemistry, medical chemistry and molecular biology, university of catania, italy cristina russo department of biochemistry, medical chemistry and molecular biology, university of catania, italy mariano malaguarnera department of internal medicine and systemic diseases, university of catania, italy +39-0957262008, [email protected]; department of internal medicine and systemic diseases, university of catania, italy +39-0957262008, [email protected]

2013
Akihito Tsubota Tomomi Furihata Yoshihiro Matsumoto Kan Chiba

Direct-acting antivirals (DAAs) in combination with pegylated IFN-a and ribavirin drastically improve the rates of rapid virological response (RVR) and sustained virological response (SVR) in the treatment of chronic hepatitis C virus infection, specifically in difficult-to-cure hepatitis C virus genotype 1. At present, RVR is an important milestone highly predictive of SVR. Response-guided the...

2014
Cristina Popescu Gabriel Adrian Popescu Alina Lobodan Mihaela Rădulescu Anca-Ruxandra Negru Roxana Petre Violeta Molagic Cristina Covaliov Adriana Manea Victoria Aramă

Background Although the ideal end point of chronic HBV hepatitis therapy is HBsAg loss, a realistic end point is the induction of sustained virological remission. The definitions of virological responses vary according to therapeutic regimen: viral load <2000 IU/mL after interferon (IFN) regimens and undetectable HBV-DNA during nucleoside/nucleotide analogues (NNA) regimens. Objective: To compa...

Journal: :P & T : a peer-reviewed journal for formulary management 2012
Walter Alexander

A phase 2 study of an interferon-free combination daclatasvir (BMS-790052, Bristol-Meyers Squibb) plus GS-7977 (formerly PSI-7977, Pharmasset/Gilead), with or without ribavirin, showed that this regimen was well tolerated and that treatmentnaive patients with hepatitis C virus (HCV) genotype 1, 2, and 3 infection achieved high rates of early sustained virological responses (SVRs). Investigators...

Journal: :hepatitis monthly 0
yoshio aizawa department of gastroenterology and hepatology, jikei university school of medicine, tokyo, japan; department of gastroenterology and hepatology, jikei university school of medicine, tokyo, japan , +81-336032111 noritomo shimada department of gastroenterology and hepatology, shinmatsudo chuo general hospital, chiba, japan hiroshi abe department of gastroenterology and hepatology, jikei university school of medicine, tokyo, japan nobuyoshi seki department of gastroenterology and hepatology, jikei university school of medicine, tokyo, japan yuta aida department of gastroenterology and hepatology, jikei university school of medicine, tokyo, japan haruya ishiguro department of gastroenterology and hepatology, jikei university school of medicine, tokyo, japan

conclusions examination of the fasting lipid profile has clinical importance in predicting the efficacy of peg-ifn-α-2b plus rbv combination therapy for patients with hcv g1b even after the discovery of the il28 genotype as a potent predictive factor. objectives to re-examine the significance of lipoprotein profiles on virological response to peg-ifn plus rbv combination therapy in patients wit...

Journal: :jundishapur journal of microbiology 0
fateme zare department of immunology, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran hossein hadinedoushan department of immunology, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran; department of immunology, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran. tel: +98-3536285406, fax: +98-3536238561 mohsen akhondi meybodi depatment of gastrology, faculty of medicine, shahid sadoughi hospital, shahid sadoughi university of medical sciences, yazd, ir iran mahdi dehghanmanshadi department of immunology, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran seyyed ali mirghanizade bafghi department of immunology, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran mahmood vakili department of community, faculty of medicine, shahid sadoughi university of medical sciences, yazd, ir iran

conclusions our findings indicate that patients with the homozygous cc genotype in the il28b gene had a significantly higher rate of response to treatment than those with the tt or ct genotypes. nor does the il28b rs12979860 polymorphism affect the viral load. results the genotype frequencies of rs12979860 polymorphism in group 1 were cc (28.9%), ct (37.8%) and tt (33.3%) and in group 2 were cc...

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