iron is a pro-oxidant cofactor that may be linked to atherosclerosis progression. free iron catalyzes the generation of free radicals and free radicals promote the oxidation of lipids. reduction of body iron stores secondary to blood donation has been hypothesized to reduce lipid peroxidation. the aim of this study was to evaluate the association between blood donation and antioxidant enzymes a...

objective(s): amyotrophic lateral sclerosis (als), a fatal progressive neurodegenerative disorder, is the most common motor neuron disease in european populations. approximately 10% of als cases are familial (fals) and the other patients are considered as sporadic als (sals). among many als causing genes that have been identified, mutations in sod1 and c9orf72 are the most common genetic causes...

compelling evidence suggests that the oxidative stress plays a key role in the pathophysiology of cardiovascular disease (cvd). superoxide dismutase (sod) enzymes play a major role in detoxification of reactive oxygen species and protection against oxidative stress. we examined the possible association between a 50-bp insertion/deletion in the sod1 promoter 1684-bp upstream of the sod1 atg with...

background: superoxide radicals are produced during oxidative metabolic processes, and removed by superoxide dismutase (sod) enzymes. controversial results have been reported regarding the tissue and plasma concentration of sod in patients with breast cancer. methods: venous blood was obtained from study participants and activity of sod enzyme was determined in 100 women. comparison was made be...

the human erythrocyte is a rich raw material for the purification of cu-zn superoxide dismutase (sod). we applied a simple and rapid procedure for the purification of sod from human erythrocytes by ion exchange chromatography. the purified sod had a specific activity of 2285.6 u/mg protein and gave a single band on polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate (sd...

osteoporosis is a metabolic disease characterized by reduction in bone density and susceptibility to deformity and fracture. some studies show that osteoblasts can create inter-cellular free radicals that lead to cellular death. superoxide dismutase (sod) plays an essential role in cell defense against reactive oxygen metabolites. the purpose of this study was to measure the plasma sod activiti...

objective: ischemic preconditioning (ipc) is an endogenous phenomenon that can induce ischemic tolerance (it) in variety of organs such as brain. in this study, we examined the intermittent and prolonged normobaric hyperoxia (ho) on neurologic deficit scores, infarct volume, and superoxide dismutase activity. materials and methods: the rats were divided to four main groups. first two main grou...

Mutations in the gene encoding Cu/Zn superoxide dismutase-1 cause amyotrophic lateral sclerosis. Superoxide dismutase-1 mutations decrease protein stability and promote aggregation. The mutant monomer is thought to be an intermediate in the pathway from the superoxide dismutase-1 dimer to aggregate. Here we find that the monomeric copper-apo, zinc-holo protein is structurally perturbed and the ...