Abstract Introduction: Isolated perfused heart models such as perfusion and superfusion are commonly used for mammalian heart research. However, there are several fundamental limitations in the current techniques. In perfusion model, a suitable cannula is connected to the aorta and the perfusion is retrogradely performed. But, electrode displacement is a potential unwanted event resulted fr...

Tilapia (Oreochromis mossambicus] teleostei) melanin-concentrating hormone gene-related peptide (tMgrp) was tested for tropic actions on adenocorticotropin hormone (ACTH) and a melanocyte s t im u la t in g ho rm one ( a M S H ) producing cells in the tilapia pituitary gland in vitro. Up to 100 pM synthetic tilapia Mgrp (tMgrp) had no effect on a -M S H release from tilapia neurointermediate lo...

Diethyl p-nitrophenyl phosphate (paraoxon) is the active toxic metabolite of parathion. Some evidences indicate that OPs affect the GABA system via noncholinergic mechanisms. The purpose of this study was to investigate the effects of paraoxon on K+-evoked [3H]-GABA release from cerebellar synaptosomes. Adult male rats (200 ± 30 g; 3-4 months old) were sacrificed by decapitation and the cerebel...

Diethyl p-nitrophenyl phosphate (paraoxon) is the active toxic metabolite of parathion. Some evidences indicate that OPs affect the GABA system via noncholinergic mechanisms. The purpose of this study was to investigate the effects of paraoxon on K+-evoked [3H]-GABA release from cerebellar synaptosomes. Adult male rats (200 ± 30 g; 3-4 months old) were sacrificed by decapitation and the cerebel...

introduction: compounds which are used to treat organophosphate (op) poisoning are not able to fully alleviate long lasting effects. they are mainly used to antagonize cholinergic effects of ops. however, non-cholinergic effects, such as interference with different neurotransmitter systems, especially gaba release and uptake, are recently attracting more attentions. we have tried to investigate...