Fast dissolving tablets are solid unit dosage forms that dissolve or disintegrate quickly in the mouth without using water. To provide this type of character a form, different excipients required. Superdisintegrants class novel agents have emerged recent years. Improving drug bioavailability pharmaceutical field is challenge. The inclusion superdisintegrants formulation enhances formulation's e...

In present study, the fast dissolving tablets of Amoxicillin Trihydrate were prepared by direct compression technique using microcrystalline cellulose (MCC) as direct compressible diluents. Sodium starch glycolate (SSG) and croscarmillose sodium (CCS) used as synthetic superdisintegrants. The swelling indices of the superdisintegrants were also compared. Among both the superdisintegrants, crosc...

In the present investigation, a novel multifunctional co-processed superdisintegrants consisting of crospovidone and Kyron T-314 were fabricated by solvent evaporation method to develop melt-in-mouth tablets of metoclopramide hydrochloride with a view to enhance patient compliance by direct compression method. The simple physical blends and co-processed mixture of superdisintegrants were charac...

An attempt has been made for the development of Orodispersible tablet of Etoricoxib by direct compression method.Sodium starch glycolate, Crospovidone, Croscarmellose, and Ludiflashwere used as a Superdisintegrants for the formulation. Twenty formulation having Superdisintegrants at different concentration (3, 6, 9, 12 %) level were prepared using microcrystalline cellulose as a direct compress...

Aceclofenac, a non-steroidal antiinflammatory drug, is used for posttraumatic pain and rheumatoid arthritis. Aceclofenac fast-dispersible tablets have been prepared by direct compression method. Effect of superdisintegrants (such as, croscarmellose sodium, sodium starch glycolate and crospovidone) on wetting time, disintegration time, drug content, in vitro release and stability parameters has ...

An oral solid dosage form should ideally disperse into the primary particles from which it was prepared. Tablets and capsules which need rapid disintegration, the inclusion of the right disintegrant is a prerequisite for optimal bioavailability. Superdisintegrants are used to improve the efficacy of solid dosage forms. This is achieved by decreasing the disintegration time which in turn enhance...

The objective of the present study is to develop a pharmaceutically stable, cost effective and quality improved robust formulation of Valsartan Immediate Release tablets. The aim of work is related to the formulation and evaluation of 10mg of dispersible tablet. Valsartan belongs to a class of antihypertensive agents called angiotensin II receptor blockers (ARBs). Total nine formulations were p...

The present work was aimed at formulation development, evaluation and comparative study of the effects of superdisintegrants in Cefixime 50 mg oral disintegrating tablets. The superdisintegrants used for the present study were sodium starch glycolate and crosscarmellose sodium. The formulated tablets were evaluated for various tableting properties, like hardness, thickness, friability, weight v...

In tablet formulation superdisintegrants are added to accelerate the rate of tablet deaggregation and thus enhancing the rate of tablet dissolution. In this review article we gather the information related to the superdisintegrants, their mechanism of actions and their impact on disintegration and dissolution processes. The easiest way to achieve quick release is to use a superdisintegrants wit...