Treatment of hemoglobin with H&S and 02 gives rise to the formation of a green pigment, sulfhemoglobin. In contradistinction to the transformation of hemoglobin into HbOz, HbCO, Meth-Hb, and other hemoglobin derivatives the transformation into sulfhemoglobin is not reversible. The nature of this reaction is as yet unknown (1). An attempt.was made therefore to isolate the prosthetic group of sul...

SULFHEMOGLOBIN is a rare cause of cyanosis that is usually drug induced. The effects of sulfhemoglobin on pulse oximetry have not been reported widely. We present the case of a 48-yr-old woman who was scheduled to undergo palliative surgery. Before anesthesia, she had an oxygen saturation, measured by pulse oximetry (SpO2), of 85%. This apparent desaturation subsequently was discovered to be th...

Sulfhemoglobins were prepared from hemoglobin A and carboxypeptidase A-treated hemoglobin. The synthesis was achieved by oxidation of the ferric hemoglobins with H,O, followed by reaction with excess hydrosulfide. ERR spectra of these ferric sulfhemoglobins at high pH were well resolved from the resonances of contaminating ferric hemoglobins. Thus, quantitative ERR measurements provided a conve...

Sulfhemoglobin is formed by the irreversible bonding of sulfur atoms to heme molecule. Oxygen then unable bind molecule, rendering hemoglobin molecule carry oxygen. The most common etiology sulfhemoglobinemia use/misuse sulfur-containing medications such as AZO. Unlike methemoglobin, sulfhemoglobin, due its binding, has no antidote, and treatment ultimately supportive. We present a case 53-year...