The effects of sulfanilic acid, a major azo food dye metabolite, were studied in normal developing rat pups and pups treated with 6-hydroxydopamine (60HDA). Chronic daily intraperitoneal injection of sulfanilic acid during the first postnatal month elicited hyperactivity and impaired shock escape performance in vehicle pups. No differences were noted in 60HDA treated rat pups receiving sulfanil...

A new technic for the determination of total bilirubin is reported. The substitution of 2,4 dichloroaniline for sulfanilic acid results in a very stable diazotized reagent which reacts quickly with bilirubin in plasma or serum. Comparison with a sulfanilic acid procedure indicates that similar analytic values are obtained with this technic; short quality control studies indicate satisfactory pr...

Alzheimer's disease is neurodegenerative disorder due to the accumulation of amyloid- β in the brain and causes dementia with ageing. Some researches indicate that the RXR agonist, Targretin, has also been used for treatment of Alzheimer's disease in mouse models. We investigate the potent candidates as RXR agonists from the vast repertoire of TCM compounds in TCM Database@Taiwan. The potential...

The response of guinea pig macrophages to migration inhibitory factor (MIF) is altered by several chemical treatments. Treatment of macrophages with the diazonium salt of sulfanilic acid (5 x 10(-6) to 4 x 10(-4) M) significantly increases the response of these cells to MIF. Treatment with acetic anhydride also augments the response of these cells to MIF. The latter finding suggests that altera...

We compared five methods for the determination of total and direct bilirubins in serum samples from normal controls, subjects with Gilbert's syndrome, and serum pools containing about 50 and 150 mg of total bilirubin per liter. The Kodak Ektachem method and a diazotized sulfanilic acid method with 0.15 mmol/L sodium nitrite concentrations are the only methods that gave accurate direct bilirubin...

The polyamine (PA) was prepared by condensation of 1, 4-bischloromethyl benzene and 1, 4benzene diamine. The PA was then treated with cyanuric chloride at 0oC followed by reaction with sulfanilic acid in THF in concentrated NaOH (pH 9-10) at room temperature for 8 hrs. The resultant polymer designated as polyamine-s-triazine-sulfanilic acid (PATS) was characterized by elemental analysis, IR spe...

The effects of surface modifications of multi-walled carbon nanotubes (MWCNTs) on their dispersibility in different solvents and poly (ether ether ketone) (PEEK) have been studied. MWCNTs were treated by mixed acids to obtain acid-functionalized MWCNTs. The acid-functionalized MWCNTs were modified with six different chemical agents separately, 1,6-diaminohexane, hexadecyl trimethyl ammonium bro...

We report the kinetics of the reactions of unconjugated bilirubin and conjugated bilirubin with p-diazobenzene sulfonic acid in aqueous media. Our studies confirm that each reaction proceeds in two steps and that the second step is catalyzed by sulfanilic acid. In the presence of an excess of p-diazobenzenesulfonic acid and in the absence of sulfanilic acid, the reaction for either unconjugated...