this study aimed to investigate the effects of different doses of sulfadiazine on embryonic chicken pectoral muscles. in total, 100 fertile eggs were obtained and divided into five groups of control (no injection) and sulfadiazine injection at doses of 2, 10, 30, and 70 mg/kg. after hatching, pectoral muscle tissues were harvested from the newly hatched chickens for histopathological examinatio...

Treatment of acute burn wounds with silver sulfadiazine has raised concern of potential silver toxicity. As the wound heals, a barrier forms between the silver sulfadiazine and the blood, but this membrane is not impenetrable, and so silver absorption is still possible. In this work, we have modeled chemical systems to investigate the transport of silver sulfadiazine and silver chloride through...

Studies by Feinstone, Williams, Wolff, Huntington, and Crossley4 on the toxicity, absorption, and chemotherapeutic activity of this compound in mice, dogs, and monkeys indicate that it exhibits less acute and chronic toxicity than either sulfapyridine or sulfathiazole. In addition, these investigators found sulfadiazine to be readily absorbed, eliminated comparatively slowly, and acetylated to ...

The toxicity of ionizable organic compounds to organisms depends on the pH, which therefore affects risk assessments of these compounds. However, there is not a direct chemical method to predict the toxicity of ionizable organic compounds. To determine whether hollow-fiber liquid-phase microextraction (HF-LPME) is applicable for this purpose, a three-phase HF-LPME was used to measure sulfadiazi...

Silver sulfadiazine cream has been a standard treatment for burns over the past two decades. Although many studies have described the phenomenon of silver absorption from burn wounds treated with silver sulfadiazine, they failed to examine the chemistry underlying the absorption process: Silver chloride was assumed to form at the burn wound and absorption of silver was believed to be negligible...

Introduction: Celosia argentea (Amaranthaceae; CA), is applied for the management of several conditions including, wounds, haemorrhagic conditions, and gynaecological diseases. Alcoholic and ethyl acetate extracts of the CA leaves, as an ointment formulation (10% w/w), were assessed for the healing efficacy on rat burn wound models and was compared with silver sulfadiazine and in vitro cytoxici...

Ionic silver has a long history as an antimicrobial in human health care. This article is a review of the published literature on how ionic silver may enter the body from exposure to silver-containing wound care products and its eventual metabolic fates, in an assessment of the safety during normal use of these products in wound care. Following the application to breached skin, there appears to...

The role of silver and sulfadiazine in the mechanism of action of silver sulfadiazine on burn wound infections was investigated. Silver, but not sulfadiazine, was bound by bacteria. Sulfadiazine did not act as an antibacterial agent in low concentrations, but exhibited specific synergism in combination with subinhibitory levels of silver sulfadiazine. The efficacy of silver sulfadiazine is thou...

OBJECTIVE To analyze morphological characteristics and organization of the collagen fibers of third degree burns from scalding compared to laser therapy and silver sulfadiazine, the latter considered as the gold standard. METHOD Were selected 12 animals (Rattus norvegicus) also divided into three groups (control group [CG] - untreated burns; sulfadiazine group [SG] - burns were treated with s...