Rotenone is a pesticide that has been shown to cause degeneration of dopaminergic neurons within the substantianigra and striatum. In this study, we investigated the protective effects of Apigenin on rotenone induced dopaminergic neurotoxicity. Adult male wistar albino rats were injected with rotenone (6μg/1μl in DMSO) or vehicle (1μl DMSO) into the right substantianigra pars compacta (SNpc) un...

The idiopathic Parkinson’s disease (PD) results from a degeneration of dopamine-producing cells in the substantianigra which leads to cardinal symptoms of hypokinesia, bradykinesia, postural instability, rigidity and tremor. These symptoms lead to difficulties in motor performance such as gait ability and falls. Even optimal medication therapy, gait problems associated with PD are often charact...

Parkinson's disease (PD) is a rather common movement disorder as a result of the degeneration of dopaminergic neurons within the substantianigra. Current treatments for PD afford symptomatic relief with no prevention of disease progression. Due to the neuroprotective and anti-apoptotic potential of the isoquinoline alkaloid berberine (BBR), this study was conducted to assess whether BBR pretrea...

Parkinson’s disease (PD) is a rather common movement disorder as a result of the degeneration of dopaminergic neurons within the substantianigra. Current treatments for PD afford symptomatic relief with no prevention of disease progression. Due to the neuroprotective and anti-apoptotic potential of the isoquinoline alkaloid berberine (BBR), this study was conducted to assess whether BBR pretrea...

Parkinson’s disease (PD) is a rather common movement disorder as a result of the degeneration of dopaminergic neurons within the substantianigra. Current treatments for PD afford symptomatic relief with no prevention of disease progression. Due to the neuroprotective and anti-apoptotic potential of the isoquinoline alkaloid berberine (BBR), this study was conducted to assess whether BBR pretrea...

Parkinson disease (PD) is the second most common progressive neurodegenerative disorder due to loss neurons in SubstantiaNigra pars compacta. A number of medical and surgical treatments are currently available but the beneficial effects wear off with long term use and many native therapies have severe side effects. Hence novel therapeutic strategies continue to be in the developmental demand. N...

Parkinson's disease is a neurodegenerative disorder associated with loss of dopaminergic neurons in substantianigra caused by severe neuro-degeneration, which is the second most common neurodegenerative disorder after Alzheimer’s disease.Parkinson's disease has a high prevalence of psychiatric comorbidity including depression. The neuropsychiatric symptoms are common in Parkinson's disease and ...

arkinson’s disease (PD) is a neurodegenerative disease relating to progressive degeneration of dopaminergic neurons in the substantianigra. The diagnostic criteria of PD were defined in a clinico-pathological study proposed by United Kingdom Parkinson’s Disease Society (UKPDS) in 1988. The consequence of degeneration of these neurons is depletion of dopamine in the central nervous system. There...

parkinson’s disease (pd) is a rather common movement disorder as a result of the degeneration of dopaminergic neurons within the substantianigra. current treatments for pd afford symptomatic relief with no prevention of disease progression. due to the neuroprotective and anti-apoptotic potential of the isoquinoline alkaloid berberine (bbr), this study was conducted to assess whether bbr pretrea...