Here, we describe the alterations of neurotransmitters and neuropeptides that act on specific subreceptors in the brain areas involved in generalized epilepsy. A neurotransmitter imbalance between GABAergic and serotonergic neurons with hypoactivity and glutaminergic and dopaminergic neurons with hyperactivity is described. Considering the alterations in neurotransmitters and neuropeptides, neu...

while for a long time it has been perceived that neonates and young children do not perceive pain as the adult, this notion had to be corrected on the basis of neurophysiological data and the ontogenisis of the nociceptive system. also, it has been demonstrated conclusively that neonates and the young infant perceive pain at a much lower nociceptive input which is largely due to a still immatur...

BACKGROUND Serotonin (5-HT) 1A and 2A receptors have been associated with dysfunctional emotional processing biases in mood disorders. These receptors further predominantly mediate the subjective and behavioral effects of psilocybin and might be important for its recently suggested antidepressive effects. However, the effect of psilocybin on emotional processing biases and the specific contribu...

Dopamine (DA) is involved in learning and memory formation, which are thought to depend on synaptic modifications like long-term potentiation (LTP) and long-term depression (LTD). Despite huge efforts to unravel the dopaminergic impact on these functions, the respective knowledge is still far from being complete. This might especially be due to the neuromodulatory impact of DA on cortical funct...

The aim of the thesis was to investigate in male Wistar rats, the involvement of serotonin (5-HT) and 5-HT receptors in the regulation of the gene expression of hypothalamic hormones and in the secretion of the pituitary gland hormones prolactin (PRL), adrenocorticotropic hormone (ACTH), vasopressin (AVP) and oxytocin in basal and stress conditions. Furthermore, to study the significance of som...