نتایج جستجو برای: subcutaneous human preadipocyte

تعداد نتایج: 1671344  

Journal: :acta medica iranica 0
i. ragerdi kashani m. barbarestani f. etesam m. a. shokrgozar m. a. abdolvahabi p. haddad

cancer cell-stromal cell interaction plays a crucial role in the growth and invasion of tumor cells of various organs. it has been recently suggested that adipocytes and preadipocytes, two specific types of stromal cells, affect the biological behavior of variety of breast cancer cell lines. in spite of few investigations, there is a controversy in the literatures about the effects of adipocyte...

Journal: :Diabetes 2006
Tamara Tchkonia Nino Giorgadze Tamar Pirtskhalava Thomas Thomou Matthew DePonte Ada Koo R Armour Forse Dharmaraj Chinnappan Carmen Martin-Ruiz Thomas von Zglinicki James L Kirkland

Fat depots vary in size, function, and potential contribution to disease. Since fat tissue turns over throughout life, preadipocyte characteristics could contribute to this regional variation. To address whether preadipocytes from different depots are distinct, we produced preadipocyte strains from single abdominal subcutaneous, mesenteric, and omental human preadipocytes by stably expressing h...

Journal: :American journal of physiology. Endocrinology and metabolism 2005
Tamara Tchkonia Yourka D Tchoukalova Nino Giorgadze Tamar Pirtskhalava Iordanes Karagiannides R Armour Forse Ada Koo Michael Stevenson Dharmaraj Chinnappan Andrew Cartwright Michael D Jensen James L Kirkland

Fat depots vary in function and size. The preadipocytes that fat cells develop from exhibit distinct regional characteristics that persist in culture. Human abdominal subcutaneous cultured preadipocytes undergo more extensive lipid accumulation, higher adipogenic transcription factor expression, and less TNF-alpha-induced apoptosis than omental preadipocytes. We found higher replicative potenti...

2013
Joanne C. McNelis Konstantinos N. Manolopoulos Laura L. Gathercole Iwona J. Bujalska Paul M. Stewart Jeremy W. Tomlinson Wiebke Arlt

Glucocorticoids increase adipocyte proliferation and differentiation, a process underpinned by the local reactivation of inactive cortisone to active cortisol within adipocytes catalyzed by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The adrenal sex steroid precursor dehydroepiandrosterone (DHEA) has been shown to inhibit 11β-HSD1 in murine adipocytes; however, rodent adrenals do not pr...

2014
Julie Lessard Sofia Laforest Mélissa Pelletier Mathieu Leboeuf Line Blackburn André Tchernof

Subcutaneous adipose tissue expansion through adipogenesis is increasingly recognized as a major determinant of body fat distribution and obesity-related cardiometabolic alterations. Our objective was to assess whether adipogenic rates of cultured human primary preadipocytes from the visceral and subcutaneous compartments relate to visceral obesity and cardiometabolic alterations. We recruited ...

2016
Rachel K Crowley Michael W O'Reilly Iwona J Bujalska Zaki K Hassan-Smith Jonathan M Hazlehurst Danielle R Foucault Paul M Stewart Jeremy W Tomlinson

AIMS The aim of this study was to assess depot-specific expression and secretion of secreted frizzled-related protein 2 (sFRP2) by adipose tissue and its effect on adipocyte biology. We measured serum sFRP2 concentrations in 106 patients in vivo to explore its relationship to fat mass, glycaemia and insulin resistance. METHODS Expression of sFRP2 in mouse and human tissues was assessed using ...

Journal: :American journal of physiology. Endocrinology and metabolism 2012
Alain Veilleux Julie-Anne Côté Karine Blouin Mélanie Nadeau Mélissa Pelletier Picard Marceau Philippe Y Laberge Van Luu-The André Tchernof

Adipogenesis and lipid storage in human adipose tissue are inhibited by androgens such as DHT. Inactivation of DHT to 3α-diol is stimulated by glucocorticoids in human preadipocytes. We sought to characterize glucocorticoid-induced androgen inactivation in human preadipocytes and to establish its role in the antiadipogenic action of DHT. Subcutaneous and omental primary preadipocyte cultures we...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2004
Yourka D Tchoukalova Michael G Sarr Michael D Jensen

To understand the significance of the reported depot differences in preadipocyte dynamics, we developed a procedure to identify committed preadipocytes in the stromovascular fraction of fresh human adipose tissue. We documented that adipocyte fatty acid binding protein (aP2) is expressed in human preadipocyte clones capable of replication, indicating that can be used as a marker of committed pr...

2016
Ying Peng Fen-Fen Chen Jing Ge Jia-Yu Zhu Xin-E Shi Xiao Li Tai-Yong Yu Gui-Yan Chu Gong-She Yang

MicroRNAs (miRNAs) are crucial regulatory molecules for adipogenesis. They contribute to the controlling of proliferation and differentiation of preadipocytes. Previous studies revealed an important role of miR-429 in cell invasion, migration, and apoptosis. Our previous work has shown that the expression of miR-429 in subcutaneous fat can be observed in newly born (3-day-old) Rongchang piglets...

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