نتایج جستجو برای: subcutaneous human adipocyte

تعداد نتایج: 1676266  

Journal: :acta medica iranica 0
i. ragerdi kashani m. barbarestani f. etesam m. a. shokrgozar m. a. abdolvahabi p. haddad

cancer cell-stromal cell interaction plays a crucial role in the growth and invasion of tumor cells of various organs. it has been recently suggested that adipocytes and preadipocytes, two specific types of stromal cells, affect the biological behavior of variety of breast cancer cell lines. in spite of few investigations, there is a controversy in the literatures about the effects of adipocyte...

2013
Robert W. O’Rourke Kevin A. Meyer Garen Gaston Ashley E. White Carey N. Lumeng Daniel L. Marks

INTRODUCTION Hypoxia regulates adipocyte metabolism. Hexosamine biosynthesis is implicated in murine 3T3L1 adipocyte differentiation and is a possible underlying mechanism for hypoxia's effects on adipocyte metabolism. METHODS Lipid metabolism was studied in human visceral and subcutaneous adipocytes in in vitro hypoxic culture with adipophilic staining, glycerol release, and palmitate oxidat...

2014
Ved Prakash Meena V. Seenu M. C. Sharma Saumya Ranjan Mallick Ashu Seith Bhalla Nandita Gupta Anant Mohan Randeep Guleria Ravindra M. Pandey Kalpana Luthra Naval K. Vikram Luísa M. Seoane

BACKGROUND Enlargement of adipocyte is associated with their dysfunction and alterations in metabolic functions. OBJECTIVES We evaluated the association of adipocyte size of subcutaneous and omental adipose tissue with body composition and cardiovascular risk factors in Asian Indians. METHODOLOGY Eighty (40 males and 40 females) non-diabetic adult subjects undergoing elective abdominal surg...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2002
Delphine Bastelica Pierre Morange Bruno Berthet Hélène Borghi Odile Lacroix Michel Grino Irène Juhan-Vague Marie-Christine Alessi

Elevated plasma plasminogen activator inhibitor (PAI)-1 observed during insulin resistance has been connected with an excessive PAI-1 adipose tissue secretion mainly by visceral fat. Our aim was to compare the localization of PAI-1 in human visceral and subcutaneous fats. PAI-1 secretion was also investigated in vitro during human adipocyte differentiation. PAI-1 antigen and mRNA were localized...

Journal: :Journal of nutrigenetics and nutrigenomics 2008
Xiaocun Sun Kristin L Morris Michael B Zemel

Dietary calcium inhibits adiposity, and a key underlying mechanism is suppression of calcitriol, which modulates Ca(2+) signaling and mitochondrial uncoupling in adipocytes. We demonstrated that calcitriol directly regulates adipocyte 11beta-HSD-1 expression and cortisol production in human adipocytes in vitro and dietary calcium inhibits visceral adipose tissue 11beta-HSD-1 expression in mice,...

2011
Alain Veilleux Maude Caron-Jobin Suzanne Noël Philippe Y. Laberge André Tchernof

OBJECTIVE We assessed whether subcutaneous and omental adipocyte hypertrophy are related to metabolic alterations independent of body composition and fat distribution in women. RESEARCH DESIGN AND METHODS Mean adipocyte diameter of paired subcutaneous and omental adipose tissue samples was obtained in lean to obese women. Linear regression models predicting adipocyte size in both adipose tiss...

Journal: :Hypertension 2014
Shahzya S Huda Rachel Forrest Nicole Paterson Fiona Jordan Naveed Sattar Dilys J Freeman

Obesity increases preeclampsia risk, and maternal dyslipidemia may result from exaggerated adipocyte lipolysis. We compared adipocyte function in preeclampsia with healthy pregnancy to establish whether there is increased lipolysis. Subcutaneous and visceral adipose tissue biopsies were collected at caesarean section from healthy (n=31) and preeclampsia (n=13) mothers. Lipolysis in response to ...

2015
Joan Sanchez-Gurmaches Wen-Yu Hsiao David A. Guertin

The origins of individual fat depots are not well understood, and thus, the availability of tools useful for studying depot-specific adipose tissue development and function is limited. Cre drivers that selectively target only brown adipocyte, subcutaneous white adipocyte, or visceral white adipocyte precursors would have significant value because they could be used to selectively study individu...

2010
Jean O'Connell Lydia Lynch Tom J. Cawood Anna Kwasnik Niamh Nolan Justin Geoghegan Aiden McCormick Cliona O'Farrelly Donal O'Shea

OBJECTIVE Several studies have reported the existence of a subgroup of obese individuals with normal metabolic profiles. It remains unclear what factors are responsible for this phenomenon. We proposed that adipocyte size might be a key factor in the protection of metabolically healthy obese (MHO) individuals from the adverse effects of obesity. SUBJECTS Thirty-five patients undergoing bariat...

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