نتایج جستجو برای: subchronic toxicity

تعداد نتایج: 119114  

Journal: :acta medica iranica 0
faezeh monji young researchers club (yrc), islamic azad university, pharmaceutical sciences branch (iaups), tehran, iran. hiva hossein tehrani young researchers club (yrc), islamic azad university, pharmaceutical sciences branch (iaups), tehran, iran. zahra halvaei young researchers club (yrc), islamic azad university, pharmaceutical sciences branch (iaups), tehran, iran. sepideh arbabi bidgoli department of toxicology & pharmacology, islamic azad university, pharmaceutical sciences branch (iaups), tehran, iran.

stachys lavandulifolia is used as the herbal tea and its wide and potent medical effects have been reported for the extract in animal studies. this study aimed to find the safety profile of the extract to find the appropriate doses for further human studies. the aerial parts of the plant were air-dried and the hydroalcoholic extract was obtained and concentrated by percolation method with 140 m...

Journal: :iranian journal of pharmaceutical research 0
h yazdanpanah l hosseinzadeh n bazmohammadi m kamalinejad

teucrium polium l. (tp) is widely used in traditional medicine of many countries including iran. there are various reports about pharmacological properties of tp such as calcium antagonist, anti- ulcer, anti – diabetic. there are a few reports about possible toxicological effects of this plant. in the present study we designed to evaluate the subchronic toxicity of teucrium polium total extract...

Journal: :iranian journal of basic medical sciences 0
hamid reza rasekh school of pharmacy, shahid beheshti university of medical sciences, tehran, iran leila hosseinzadeh school of pharmacy, kermanshah university of medical sciences, kermanshah, iran soghra mehri school of pharmacy, mashhad university of medical sciences, mashhad, iran mohammad kamli-nejad school of pharmacy, shahid beheshti university of medical sciences, tehran, iran majid aslani school of pharmacy, shahid beheshti university of medical sciences, tehran, iran farahnaz tanbakoosazan school of pharmacy, shahid beheshti university of medical sciences, tehran, iran

objective(s) ocimum basilicum l. is widely used in folk medicine of many countries including iran. both o. basilicum and its oil extract have received considerable attention for their potential medicinal properties, but there are a few reports about possible toxicity of this plant. therefore, in the present study, acute and subchronic toxicity of o. basilicum hydroalcohlic extract have been eva...

Journal: :iranian journal of pharmaceutical sciences 0
seyed nasser ostad department of toxicology and pharmacology, faculty of pharmacy, tehran university of medical sciences, tehran, iran, manochehr hamedi department of food industry, karaj agriculture university, karaj, iran hamidreza monsef esfahani department of pharmacognosy, faculty of pharmacy, tehran university of medical sciences, tehran, iran, seyed mohammad shariatpanahi department of toxicology and pharmacology, faculty of pharmacy, tehran university of medical sciences, azizi ebrahim department of toxicology and pharmacology, faculty of pharmacy, tehran university of medical sciences, tehran, iran, mohammad seyedabadi department of pharmacology, school of medicine faculty of pharmacy, tehran university of medical sciences, tehran, iran, mehran mohseni

toxic and direct teratogenic potential of two dominant iranian cultivars of carthamus tinctorius (safflower), floret extracts, il 111 and lrv 51 51, were investigated. the extracts are commonly used in foods and medicinal products. neither death nor alteration of stereotype activities was observed with il 111 and lrv 51 51 extracts up to 17 g/kg in 48 h in mice and rats. haemoglobin was decreas...

2014
Thamilvaani Manaharan Srikumar Chakravarthi Ammu Kutty Radhakrishnan Uma Devi Palanisamy

In this study, the acute and subchronic toxicity effect of the Syzygium aqueum leaf extract (SA) was evaluated. For the acute toxicity study, a single dose of 2000 mg/kg of the SA was given by oral-gavage to male Sprague-Dawley (SD) rats. The rats were observed for mortality and toxicity signs for 14 days. In the subchronic toxicity study the SA was administered orally at doses of 50, 100, and ...

2016
Pallavi Deshpande Vishwaraman Mohan Prasad Thakurdesai

Article history: Received on: 29/03/2016 Revised on: 07/07/2016 Accepted on: 08/08/2016 Available online: 26/09/2016 Objective: To evaluate acute oral toxicity (AOT), subchronic toxicity, and mutagenic potential of glycosides based standardized fenugreek (Trigonella foenum graecum L.) seeds extract (SFSE-G). Materials and Methods: The AOT, subchronic (90-day repeated dose) toxicity and mutageni...

Farahnaz Tanbakoosazan Hamid Reza Rasekh Leila Hosseinzadeh, Majid Aslani Mohammad Kamli-Nejad Soghra Mehri

Objective(s) Ocimum basilicum L. is widely used in folk medicine of many countries including Iran. Both O. basilicum and its oil extract have received considerable attention for their potential medicinal properties, but there are a few reports about possible toxicity of this plant. Therefore, in the present study, acute and subchronic toxicity of O. basilicum hydroalcohlic extract have been ev...

2017
Joo-Yeon Chung Jihye Lee Daeyeon Lee Eunju Kim Jae-Ho Shin Pu Reum Seok Sang-Ho Yoo Yuri Kim

BACKGROUND/OBJECTIVES Turanose, α-D-glucosyl-(1→3)-α-D-fructose, is a sucrose isomer which naturally exists in honey. To evaluate toxicity of turanose, acute and subchronic oral toxicity studies were conducted with ICR mice. MATERIALS AND METHODS For the acute oral toxicity study, turanose was administered as a single oral dose [10 g/kg body weight (b.w.)]. In the subchronic toxicity study, I...

2016
Pallavi Deshpande Vishwaraman Mohan Prasad Thakurdesai

The objective of the present study was to evaluate acute oral toxicity, subchronic toxicity, and mutagenic potential of low molecular weight galactomannans based standardized fenugreek seeds extract (LMWGAL-TF) in laboratory animals rats as per Organization for Economic Co-operation and Development (OECD) guidelines. For the acute toxicity (AOT) study, LMWGAL-TF was orally administered to Sprag...

F Mojab, M Soleimani Far, S Arbabi Bidgoli,

Background: Ferula species have shown wide range of pharmacological properties but there is no study on oral safety profile of Ferula persica due to standard toxicology guidelines. Objective: This study aimed to evaluate the acute and subchronic oral toxicity of the alcoholic extract of the aerial parts of Ferula persica to provide its safe dose for long term oral administrations as a possible...

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