نتایج جستجو برای: stz

تعداد نتایج: 4365  

Journal: :Journal of health sciences and medicine 2022

Aim: In our study, the therapeutic effect of resveratrol against toxicity cisplatin in rats with experimental diabetes mellitus streptozotocin was investigated.
 Material and Method: 64 were used study. 8 groups randomly formed, each group. Group 1 determined as control 2 (STZ) injected 60 mg/kg intraperitoneally (ip) on first day to induce diabetes. 3 (RES) given 100 orally every day. 4 (...

Journal: :Black sea journal of health science 2023

Protein kinase C (PKC) is a promoter enzyme that plays vital role in signal transduction of vascular smooth muscle cells (VSMCs). It has numerous functions, such as cell growth, cytokine activation and angiogenesis. But, these mechanisms are deteriorating diabetes mellitus. Angiotensin II (Ang II) effects on structure binding Ang type-1 type-2 receptors (ATR1 ATR2) stimulates PKC mostly through...

Journal: :American journal of physiology. Cell physiology 2007
Adam P W Johnston Jonathan E Campbell Jeremy G Found Michael C Riddell Thomas J Hawke

Streptozotocin (STZ) is used extensively to induce pancreatic beta-cell death and ultimately diabetes mellitus in animal models. However, the direct effects of STZ on muscle are largely unknown. To delineate the effects of STZ from the effects of hypoinsulinemia/hyperglycemia, we injected young rats with 1) saline (control), 2) STZ (120 mg/kg) or 3) STZ and insulin (STZ-INS; to maintain euglyce...

Journal: : 2023

85 years ago, on 11 July 1937, the production of STZ-NATI, famous and deservedly popular tracked agricultural tractor, was launched at Stalingrad Tractor Plant. This tractor first which had completely domestic deisgn. Development this is an example effective collaboration between design engineers STP scientists All-soviet Scientific Research Insitute (NATI). In comparison with predecessor, STZ-...

Journal: :Current protocols 2021

Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β-cell destruction and widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ-induced insulin deficiency hyperglycemia mice rats. Also described creating animal models 2 using STZ. These animals employed assessing the pathological consequences sc...

2016
Valentina K Bayrasheva Alina Yu Babenko Vladimir A Dobronravov Yuri V Dmitriev Svetlana G Chefu Ivan Yu Pchelin Alexandra N Ivanova Alekber A Bairamov Nina P Alexeyeva Ivan S Shatalov Elena N Grineva

Type 2 diabetes (DM2) could be reproduced in rats with alimentary obesity by using low doses of streptozotocin (LD-STZ) as well as STZ in high doses with preliminary nicotinamide (NA) administration. However, STZ could induce tubulotoxicity. Aim. To develop rat model of DN in NA-STZ-induced DM2 and compare it with LD-STZ-model in order to choose the most relevant approach for reproducing renal ...

Journal: :Cardiovascular research 2014
Shotaro Saito Yasushi Teshima Akira Fukui Hidekazu Kondo Satoru Nishio Mikiko Nakagawa Tetsunori Saikawa Naohiko Takahashi

AIMS We investigated whether glucose fluctuations aggravate cardiac fibrosis and increase the occurrence of atrial fibrillation (AF) in rats with diabetes mellitus (DM). METHODS AND RESULTS Streptozotocin-induced diabetic rats were randomly divided into three groups: uncontrolled DM (U-STZ) group, controlled DM (C-STZ) group, and DM with glucose fluctuations (STZ-GF) group. Glucose fluctuatio...

2017
Koji Sato Takeshi Nishijima Takumi Yokokawa Satoshi Fujita

Previous studies have demonstrated that an acute bout of aerobic exercise induces a subsequent delayed onset of hypoglycemia among patients with type 1 diabetes. However, the mechanisms of exercise-induced hypoglycemia in type 1 diabetes are still unclear. Streptozotocin (STZ) was injected to 6-week-old male Wistar rats, and three days after STZ injection, animals were randomly assigned into 2 ...

Journal: :Experimental Diabesity Research 2003
Isabel M. Martínez Inmaculada Morales Guadalupe García-Pino José E. Campillo María A. Tormo

Diabetes in humans and in experimental animals produces changes in the function and structure of the small intestine. The authors determined the activity of intestinal disaccharidases (maltase and sucrase) and of 6-phosphofructo-1-kinase (PFK-1) in enterocytes isolated from the small intestine of male Wistar rats (2.5 to 3 months old) with experimental nonobese type 2 diabetes, induced by strep...

2006
NoRIKO SAKAGUCHI TosHIKo TOKORO FANGZHENG WANG TAMAYO KADOBAYASHI YUKO IMAI

We investigated the effects of streptozotocin (STZ)-induced diabetes on thyroid hormone levels, type 1 deiodinase (D1) activity and messenger RNA (mRNA) levels in inherited D1 deficient C3H mice in a comparative manner with control C57 mice. The apparent maximum velocity (Vmax) D1 values in C3H mice were 3% (liver) and 26% (kidney) of those in C57 mice. In C3H mice, similar serum T3, slightly h...

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