conclusions hcv gpe2 is an ideal target for hcv vaccine. prediction of epitope immunogenicity and characterization on the basis of peptide sequences will be significantly helpful for development of a heterologous vaccine against hcv variants. results many b-cell and t-cell epitopes predicted in gpe2 were found conserved among hcv 3a genotypes whereas few were conserved in other genotypes antici...

Topological and geometrical methods constitute common tools for the analysis of high-dimensional scientific data sets. Geometrical methods such as projection algorithms focus on preserving distances in the data set. Topological methods such as contour trees, by contrast, focus on preserving structural and connectivity information. By combining both types of methods, we want to benefit from thei...

We construct a stable homotopy refinement of quantum annular homology, link homology theory introduced by Beliakova, Putyra and Wehrli. For each $r\geq 2$ we associate to an $L$ naive $\mathbb{Z}/r\mathbb{Z}$-equivariant spectrum whose cohomology is isomorphic the as modules over $\mathbb{Z}[\mathbb{Z}/r\mathbb{Z}]$. The construction relies on equivariant version Burnside category approach Laws...

Abstract Simplicial complexes are generalizations of classical graphs. Their homology groups widely used to characterize the structure and topology data in e.g. chemistry, neuroscience, transportation networks. In this work we assume given a simplicial complex that can act on its underlying graph, formed by set 1-simplices, investigate stability with respect perturbations edges such graph. Prec...

As structural genomics (SG) projects continue to deposit representative 3D structures of proteins, homology modeling methods will play an increasing role in structure-based drug discovery. Although computational structure prediction methods provide a cost-effective alternative in the absence of experimental structures, developing accurate enough models still remains a big challenge. In this con...

Several studies show that transcription coactivators are often bi-functional ribonucleoprotein complexes that also regulate pre-mRNA processing and splicing decisions. Using sensitive sequence profile searches and structural comparisons we show that the C-terminal domain of the human coactivator protein ASC-1 defines a novel superfamily, the ASC-1 homology (ASCH) domain. The approximately 110 a...