The effect of Strobilanthes crispus extract and glycyrrhizin in on rats induced with carcinoma is reported. The results showed significant, increase of liver microsome glutathione s-transferase (GST) in rats after 12 weeks. Treatment with glycyrrhizin caused decrease in liver GST activity compared to control. Treatment with Strobilanthes crispus extract caused overall decrease in liver GST acti...

BACKGROUND Strobilanthes crispus has been traditionally used as antidiabetic, anticancer, diuretic, antilytic and laxative agent. However, cytotoxicity and antiproliferative effect of S. crispus is still unclear. RESULTS Strobilanthes cripus was able to reduce cell viability and proliferation in MTT and BrdU assays. Both cell cycle progression and Tunel assay suggested that IC50 of S. crispus...

In this work, microscopic and histological studies suggest that Strobilanthes crispus ethanol extract reduce azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) in rats. S. crispus is considered a traditional medicine and used as an antioxidant. Its leaf contains a large amount of phenolic compounds to which its radical scavenging role is attributed and enhance its ability to eradicate...

BACKGROUND Strobilanthes crispus is a well-known herb in Malaysia with various pharmaceutical properties. S. crispus is known to contain several biologically active chemical constituents which are responsible for its pharmaceutical quality. METHODS Strobilanthes crispus leaves grown in three different locations in Malaysia [Kelantan (North-east), Selangor (Central), and Penang (North)], were ...

BACKGROUND With cancer being one of the major causes of death around the world, studies are ongoing to find new chemotherapeutic leads. There are common mechanisms for colorectal cancer (CRC) formation. Several are connected with oxidative stress-induced cell apoptosis and others are related to imbalanced homeostasis or intake of drugs/toxins. Plants that have been used for decades in folk and ...

Cancer is a major cause of death worldwide, as exemplified by millions cancer diagnoses every year. The use chemotherapy in treating has many disadvantages which include recurrence cancer, associated with drug resistance, and severe side effects that are harmful to the patients. A better source anticancer drugs can come from nature. Strobilanthes crispus (S. crispus) herbal medicinal plant indi...

abstract objective : in this study, we have undertaken efforts to ascertain the anticancer potency of s. crispus (sc) extract on diethylnitrosamine (den) and acetylaminofluorene (aaf) induced hcc with special attention to hepatic drug metabolism and to investigate the effect of sc on preneoplastic marker enzyme activity specifically of microsomal aniline hydroxylase (ah) activity and lesion sco...

Cancer patients seek alternative remedies such as traditional medicinal plants for safe and effective treatment and help overcome the side effects of conventional therapy. Current knowledge indicates that extracts of Strobilanthes crispus of the Acanthaceae family exhibit potent anticancer properties in vitro and are non-toxic in vivo. S. crispus was also reported to be protective against chemi...

BACKGROUND Development of tumour resistance to chemotherapeutic drugs and concerns over their toxic effects has led to the increased use of medicinal herbs or natural products by cancer patients. Strobilanthes crispus is a traditional remedy for many ailments including cancer. Its purported anticancer effects have led to the commercialization of the plant leaves as medicinal herbal tea, althoug...

Phytochemical investigation of Strobilanthes crispus has led to the isolation of 1-heptacosanol (1), tetracosanoic acid (2), stigmasterol (3) from the hexane extract, a mixture of four C20-C24 fatty acid esters of βamyrin (4), taraxerol (5), taraxerone (6), a mixture of two C22 and C24 fatty acid esters of taraxerol (7) from the dichloromethane extract, 4-acetyl-2,7-dihydroxy-1,4,8-triphenyloct...