background: ventilator-associated pneumonia (vap) increases the cost of intensive care unit (icu) treatment and the chance of mortality. due to the increasing use of proton pump inhibitors (ppi) and h2 receptor inhibitors for stress ulcer prophylaxis, the purpose of the study was to investigate the differences of vap in two groups of patients receiving ppi or h2 blocker. methods: in the retrosp...

stress-related mucosal damage (srmd) is a significant cause of morbidity and mortality in critically ill patients due to the gastrointestinal blood loss. prophylaxis of srmd with proton pump inhibitors or histamine-2 blockers has gained widespread use in intensive care units. both demonstrated to be effective in reducing clinically significant bleedings, while ppis has shown to exert some anti ...

background: this study aimed to compare intermittent intravenous (iv) pantoprazole and ranitidine for control of gastric acid secretion and the possible prevention of upper gastrointestinal bleeding (ugib) in critical care patients. methods: this was a randomized, double blind clinical trial study of iv pantoprazole (40 mg every12 hour) or intermittent iv ranitidine (50 mg bolus every 8 hour) i...

The influence of stress on the clinical course of a number of intestinal diseases is increasingly being recognized, but the underlying mechanisms are largely unknown. This themes article focuses on recent findings related to the effects of stress on mucosal barrier function in the small intestine and colon. Experiments using animal models demonstrate that various types of psychological and phys...

background: the airway surfaces are one of the most common ways of entry of infectious agents. oral cavity associated lymphoid tissues are inductive site of humoral immune responses in inflammatory and infectious disorders of the upper respiratory tract. these lymphoid tissues play important roles in the induction of salivary iga. the impact of upper respiratory tract diseases on salivary iga p...

INTRODUCTION Salivary biomarkers are suggested to provide a reliable, noninvasive and objective measurement of chronic psychosocial stress and helps in assessment of pivotal role of stress in causation or precipitation of multitude of health problems. OBJECTIVES To evaluate the usefulness of salivary alpha amylase activity as an objective indicator of chronic stress and to find out any correl...

Stress ulceration is single or multiple mucosal defects with/without bleeding from the gastric mucosa during the physiologic stress. Oxidative stress (OS) is a key pathogenic factor in psychogenic stress-induced acute gastric mucosal lesion (AGML). Fermented papaya preparation (FPP) is reported to have oxygen radical scavenging activity and is effective in OS-related diseases. Here, we investig...