this paper highlights the effect of silt content on cone tip resistance in loose silty sand. in this study, twenty-seven cone penetration tests are performed in saturated silty sand samples with several different silt contents ranging from 10 to 50 percent. the samples are consolidated at three overburden stresses including 100, 200 and 300 kpa. it is shown that, as the silt content increases, ...

Background: Long-lasting hyperglycemia in type 1 diabetic patients induces permanent alterations of endothelial function, by increased oxidative stress, even when glycemia is normalized. Methods and Results: In this study 36 type 1 diabetic patients and 12 controls were enrolled. The diabetic patients were divided in three groups. The first group was treated for 24h with insulin, achieving a ne...

Jatropha curcas is a promising renewable feedstock for biodiesel and bio-jet fuel production. To study gene expression in Jatropha in different tissues throughout development and under stress conditions, we examined a total of 11 typical candidate reference genes using real-time quantitative polymerase chain reaction (RT-qPCR) analysis, which is widely used for validating transcript levels in g...

To accurately measure gene expression using quantitative reverse transcription PCR (qRT-PCR), reliable reference gene(s) are required for data normalization. Corchorus capsularis, an annual herbaceous fiber crop with predominant biodegradability and renewability, has not been investigated for the stability of reference genes with qRT-PCR. In this study, 11 candidate reference genes were selecte...

Normalization to reference genes is the most common method to avoid bias in real-time quantitative PCR (qPCR), which has been widely used for quantification of gene expression. Despite several studies on gene expression, Lilium, and particularly L. regale, has not been fully investigated regarding the evaluation of reference genes suitable for normalization. In this study, nine putative referen...

OBJECTIVE Long-lasting hyperglycemia in type 1 diabetic patients induces permanent alterations of endothelial function by increased oxidative stress, even when glycemia is normalized. RESEARCH DESIGN AND METHODS In this study, 36 type 1 diabetic patients and 12 control subjects were enrolled. The diabetic patients were divided into three groups. The first group was treated for 24 h with insul...

Targeted therapies aimed at tumor vasculature are utilized in combination with chemotherapy to improve drug delivery and efficacy after tumor vascular normalization. Tumor vessels are highly disorganized with disrupted blood flow impeding drug delivery to cancer cells. Although pharmacologic anti-angiogenic therapy can remodel and normalize tumor vessels, there is a limited window of efficacy a...

Yorek, Mark A., Joyce A. Dunlap, Wenli Liu, and William L. Lowe, Jr. Normalization of hyperosmoticinduced inositol uptake by renal and endothelial cells is regulated by NF-kB. Am J Physiol Cell Physiol 278: C1011– C1018, 2000.—Hyperosmolarity is a stress factor that has been shown to cause an increase in the transcription of the Na1-dependent myo-inositol cotransporter (SMIT). However, regulati...

OBJECTIVE Previous studies have shown that in type 1 diabetes endothelial dysfunction persists even when glycemia is normalized. Moreover, oxidative stress has recently been demonstrated to be the mediator of hyperglycemia-induced endothelial dysfunction. RESEARCH DESIGN AND METHODS Thirty-six type 1 diabetic patients and 12 control subjects were enrolled. The diabetic patients were divided i...

BACKGROUND Normalization of brachial artery flow-mediated dilation (FMD) to individual shear stress area under the curve (peak FMD:SSAUC ratio) has recently been proposed as an approach to control for the large inter-subject variability in reactive hyperemia-induced shear stress; however, the adoption of this approach among researchers has been slow. The present study was designed to further ex...