objective: the aim of this study was to investigate the effect of pre-treatment with curcumin on metabolic changes induced by two different pathophysiological mechanisms in rats (fructose diet and streptozotocin (stz)-induced diabetes mellitus). materials and methods: five groups with 10 rats per group were investigated: control group (healthy rats), fructose diet groups without any pre-treatme...

introduction: due to the relation between structure and function of renal glomeruli, the study of glomeruli is very important to the understanding of initiation and progression of diabetic glomerulopathy. it seems that glomeruli disappear during the course of diabetic nephropathy without leaving recognizable corpuscles. this study was aimed to show diabetes mellitus effects on changes in renal ...

The Effect of Melissa officinalis Extract on Streptozotocin-Induced Diabetes in Rats: A Stereological Study Pancreatic Islets and Beta-cells

background: the present study evaluated the effects of treadmill running on extracellular basal levels of glutamate and gaba at dentate gyrus of streptozotocin-induced diabetic rats. methods: after 12 weeks of diabetes induction and exercise period, extracellular levels of glutamate and gaba were investigated. results: the results showed that glutamate levels were significantly decreased in dia...

Herbal medicine development against the non-communicable disease like diabetes is one of the thrust area of research in the field of global medicine. Here we have studied the separate and composite methanolic extract of seed of Eugenia jambolana and root of Musa paradisiaca for the management of streptozotocin-induced diabetes mellitus. We have measured the fasting blood glucose level and glyco...

Diabetes is a life-threatening disease, and currently available synthetic medicines for treating diabetes are associated with various side effects. Therefore, there an unmet need to develop herbal remedies against as alternative medicines. Although local healers use the roots of Spermadicyton suaveolens (SS) manage diabetes, negligible research validate its antidiabetic properties. The present ...

diabetes mellitus is associated with complications in several different systems of the body, and the incidence of diabetes is rapidly increasing worldwide. the objective of the present study was to evaluate the effect of aqueous extract of cydonia oblonga mill. fruit on lipid profile and some biochemical parameters in streptozotocin-induced diabetic rats. the extract showed anti hyper lipidemic...

objective(s): reproductive dysfunction is a consequence of diabetes. diabetes is associated with changes in testicular tissue. sesame oil contains large amounts of polyunsaturated fatty acids and lignin with antioxidant activity, vitamin e, and monounsaturated fatty acid (mufa). the present study investigated the effects of sesame on testis histology and male reproductive parameters in streptoz...

Diabetes mellitus both (Type 1 and Type 2) are one of the common causes for activation platelet. Inflammation-induced abnormal platelet function contributes to chronic complications, which leading death morbidity among diabetics. Rac1 has been shown regulate a variety functions; predicted Rac1could release CXCL4, leads kidney injury in Mellitus. mellitus' effect on activation, 21kD G-protein im...

The article discusses the issues about effect of Armadin on hepatic transaminase in rats with acute generalized peritonitis background diabetes mellitus. experiment was performed 48 white male adult rats, which were divided into two groups. experimental group – animals simulated against streptozotocin-induced drug “Armadin” (ethylmethylhydroxypyridine succinate) application (n=24). control with...