نتایج جستجو برای: streptokinase thrombolytic activity

تعداد نتایج: 1141962  

Journal: :avicenna journal of phytomedicine 0
md. ramjan ali department of pharmacy, noakhali science and technology university, sonapur, noakhali- 3814, bangladesh marjan hossain department of pharmacy, noakhali science and technology university, sonapur, noakhali- 3814, bangladesh jannatul ferdous runa department of pharmacy, noakhali science and technology university, sonapur, noakhali- 3814, bangladesh md. hasanuzzaman department of pharmacy, noakhali science and technology university, sonapur, noakhali- 3814, bangladesh md. mahmodul islam department of pharmacy, noakhali science and technology university, sonapur, noakhali- 3814, bangladesh

objective: the present study is aimed to investigate in vitro thrombolytic activity of three bangladeshi medicinal plants averrhoa bilimbi (oxalidiaceae), clerodendrum viscosum (verbanaceae) and drynaria quercifolia (polypodiaceae). materials and methods: each the plant was extracted with methanol at room temperature and the concentrated methanolic extracts (mef) were fractionated by the modifi...

Journal: :novelty in biomedicine 0
mahboobeh mobarrez department of biochemistry, payame noor university, mashhad branch, mashhad, iran mojgan bandehpour cellular and molecular biology research center and department of biotechnology, school of medicine, shahid beheshti university of medical sciences, tehran, iran massoud salehmoghadam department of biochemistry, payame noor university, mashhad branch, mashhad, iran bahram kazemi cellular and molecular biology research center and department of biotechnology, school of medicine, shahid beheshti university of medical sciences, tehran, iran

background: streptokinase is a bacterial protein produced by different beta hemolytic streptococci and widely used in thrombolytic treatment. the main disadvantage of using streptokinase is antibody formation which causes allergic reaction to neutralize effects of streptokinase therapy. aim of this study was investigate of recombinant mutant streptokinase fibrinolytic activity. m aterials and m...

Journal: :Blood 1985
G Agnelli M R Buchanan F Fernandez J Van Ryn J Hirsh

Tissue type plasminogen activator (t-PA) is an effective thrombolytic agent in experimental animals. The duration of the thrombolytic effect of infused t-PA is unknown. We compared the duration of the thrombolytic effect of t-PA with streptokinase by measuring the lysis of 125I-fibrin-labeled thrombi in rabbit jugular veins at different times after a bolus injection of the fibrinolytic agents. ...

Objective: The present study is aimed to investigate in vitro thrombolytic activity of three Bangladeshi medicinal plants Averrhoa bilimbi (Oxalidiaceae), Clerodendrum viscosum (Verbanaceae) and Drynaria quercifolia (Polypodiaceae). Materials and methods: Each the plant was extracted with methanol at room temperature and the concentrated methanolic extracts (MEF) were fractionated by the modifi...

Journal: :novelty in biomedicine 0
marzieh sameni department of biology, faculty of basic sciences, science and research branche, islamic azad university, tehran, iran mazaher gholipourmalekabadi cellular and molecular biology research center and biotechnology department, school of medicine, shahid beheshti university of medical sciences, tehran, iran mojgan bandehpour cellular and molecular biology research center and biotechnology department, school of medicine, shahid beheshti university of medical sciences, tehran, iran mehrdad hashemi department of genetics, islamic azad university, tehran medical sciences branch, tehran, iran farzin sahebjam department of clinical science, faculty of veterinary medicine, karaj branch, islamic azad university, karaj, iran v tohidi department of clinical science, faculty of veterinary medicine, karaj branch, islamic azad university, karaj, iran

background : immunogenicity of streptokinase (stk), as a thrombolytic drug, have limited its clinical use. elimination of the amino acid residues that are responsible for immunogenicity while don’t affect the bioactivity of stk is worthy. recently, we modified the stk through elimination of 42 amino acids from its’ c-terminal and assessed its bioactivity in vitro . objective : in this study, bi...

2005
Giancarlo Agnelli Michael R. Buchanan Francoise Fernandez Joanne Van Ryn Jack Hirsh

Tissue type plasminogen activator (t-PA) is an effective thrombolytic agent in experimental animals. The duration of the thrombolytic effect of infused t-PA is unknown. We compared the duration of the thrombolytic effect of t-PA with streptokinase by measuring the lysis of 125l-fibrinlabeled thrombi in rabbit jugular veins at different times after a bolus injection of the fibrinolytic agents. T...

Journal: :iranian journal of microbiology 0
z karimi department of biology, faculty of science, alzahra university, tehran, iran. m babashamsi department of immunochemistry, monoclonal antibody research center, avicenna research institute, acecr, tehran, iran. e asgarani department of biology, faculty of science, alzahra university, tehran, iran. m niakan department of medical microbiology,shahed university, tehran, iran. a salimi department of immunochemistry, monoclonal antibody research center, avicenna research institute, acecr, tehran, iran.

background and objectives : streptokinase is used clinically as an intravenous thrombolytic agent for the treatment of acute myocardial infarction and is commonly prepared from cultures of streptococcus equisimilis strain h46a. the objective of the present study was the production of streptokinase from strain h46a and purification by chemical reduction method. materials and methods: the rate of...

Journal: :the journal of tehran university heart center 0
mojtaba salarifar tehran heart center, tehran university of medical sciences, tehran, iran. saeed sadeghian tehran heart center, tehran university of medical sciences, tehran, iran. ali abbasi tehran heart center, tehran university of medical sciences, tehran, iran. gholamreza davoodi tehran heart center, tehran university of medical sciences, tehran, iran. alireza amirzadegan tehran heart center, tehran university of medical sciences, tehran, iran. seyed kianoosh hosseini tehran heart center, tehran university of medical sciences, tehran, iran.

background: we sought to evaluate the efficacy and safety of the different trade forms of streptokinase available in our country, namely heberkinasa (heberbiotec, havana, cuba) and streptase (aventis behring gmbh, marburg, germany). methods: we conducted a double-blind randomized clinical trial to compare the two streptokinase formulations, i.e. heberkinasa (hbk) or streptase (stp), in patients...

Journal: :avicenna journal of medical biotechnology 0

background: streptokinase is a potent activator of plasminogen to plasmin, the enzyme that can solubilize the fibrin network in blood clots. streptokinase is currently used in clinical medicine as a thrombolytic agent. it is naturally secreted by β-hemolytic streptococci. methods: to reach an efficient method of purification, an immunoaffinity chromatography method was developed that could puri...

2015
Mohammad Shahriar Nishat Zareen Khair Mahjabeen Gazi Rumana Akhter

In this present study, the bark extracts of Erythrina variegate were subjected to evaluate of the thrombolytic activity, which was assessed by using human erythrocyte and the results were compared with standard streptokinase (SK). The methanol extract showed 72.14 ± 3.77 % clot lysis as compared to 78.42 ± 1.6 % clot lysis produced by standard streptokinase.

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید