نتایج جستجو برای: strains
تعداد نتایج: 151391 فیلتر نتایج به سال:
We sequenced the complete genome of the widely used C57L/J mouse inbred strain. With 40× average coverage, we compared the C57L/J sequence with that of the C57BL/6J and identified many known as well as novel private variants. This genome sequence adds another strain to the growing number of mouse inbred strains with complete genome sequences and is a valuable resource to the scientific community.
Analysis of single-subject transcriptome response data is an unmet need of precision medicine, made challenging by the high dimension, dynamic nature and difficulty in extracting meaningful signals from biological or stochastic noise. We have proposed a method for single subject analysis that uses a mixture model for transcript fold-change clustering from isogenically paired samples, followed b...
A typical current study investigating the neurobiology of animal behavior is likely restricted to male subjects, of standard inbred mouse strains, tested in simple behavioral assays under laboratory conditions. This approach enables the use of advanced molecular tools, alongside standardization and reproducibility, and has led to tremendous discoveries. However, the cost is a loss of genetic an...
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