Cell Culture Bioreactors Basic Types of Bioreactors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1 Stirred Tank (Well Mixed) vs. Tubular Reactor (Plug Flow) . . . . . . . . . . . . . . . . . 3 Segregated Bioreactors (Dead Zone Present) Compartmentalized Bioreactors . . 4 Implication When Growth or Reaction Occurs in the Reactor . . . . . ....

This paper presents a comparative study of Continuous Stirred Tank Reactor concentration control using Particle Swam Optimization and Bacterial Forging Optimization. Continuous stirred tank reactor plays a very important role in process industry. This paper presents the optimal design of PID controller based on Particle Swarm Optimization and Bacterial Forging Optimization. The first step is th...

multiphase impeller stirred tank reactors enhance mixing of reacting species used in a variety of chemical industries. these reactors have been studied based on computational fluid dynamics (cfd) that can be used in the analysis, design and scale up of these reactors. most of the researches done in this area are limited to single phase reactors, and a few remaining two phase flow investigations...

Optimization of submerged culture conditions for the production of mycelial growth and exopolysaccharides (EPSs) by Collybia maculata was investigated. The optimum temperature and the initial pH for EPS production in a shake-flask culture of C. maculata were found to be 20°C and 5.5, respectively. Among the various medium’s constituents examined, glucose, Martone A-1, K2HPO4, and CaCl2 were the...

The non-isothermal continuous stirred tank reactor (CSTR) is a classical yet complex case study of nonlinear dynamical systems. Power-shaping control is a recent approach for the control of nonlinear systems based on the physics of the dynamical system and it rests on the formulation of the dynamics in the Brayton-Moser form. The Brayton-Moser formulation of the non-isothermal continuous stirre...

In order to operate a process which uses immobilized enzymes at constant conversion and constant capacity, the refreshment of the enzyme must be continuous. In this paper, two reactor types with continuous refreshment of the biocatalyst are discussed: the stirred tank and the multistage fluidized bed. A method is presented for dimensioning a reactor in such a way that the costs for the conversi...

In this paper the design of a nonlinear feedback controller is analyzed for concentration control of continuous stirred tank reactors (CSTR) which have strong nonlinearities. Continuous Stirred Tank Reactor (CSTR) is one of the common reactors in chemical process and all industrial process requires a solution of specific chemical strength of chemicals considered for analysis. Here Particle Swar...

This study demonstrates the applicability of pressurized stirred tank bioreactors for oxygen transfer enhancement in aerobic cultivation processes. The specific power input and the reactor pressure was employed as process variable. As model organism Escherichia coli, Arxula adeninivorans, Saccharomyces cerevisiae and Corynebacterium glutamicum were cultivated to high cell densities. By applying...

When the crisscross baffles and logarithmic spiral baffles are placed on the bottom of the stirred tank with elliptic bottom, using CFD software FLUENT simulates the velocity field of the stirred tank with elliptic bottom and bottom baffles. Compare the velocity field of stirred tank with bottom crisscross baffle to the velocity field of stirred tank without bottom baffle and analysis the flow ...

A control system based on a combination of the gain-scheduling control method and an adaptive PID controller was designed for the production of xylose from hardwood hemicellulose using a stirring tank reactor. Different operating conditions have been considered for estimating the adjustable parameter (theta) to take into account the changes of energy of the system. The performance of the contro...