Cell Culture Bioreactors Basic Types of Bioreactors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1 Stirred Tank (Well Mixed) vs. Tubular Reactor (Plug Flow) . . . . . . . . . . . . . . . . . 3 Segregated Bioreactors (Dead Zone Present) Compartmentalized Bioreactors . . 4 Implication When Growth or Reaction Occurs in the Reactor . . . . . ....

a laboratory stirred tank bioreactor with six single and dual-impeller configurations was tested to obtain the optimum operating conditions for future biological processes. six impeller combinations consisting of three basic impeller types, namely rushton turbine (rt), pitched 4blade (p4b) and pitched 2blade (p2b) downward flow were investigated in 1.77 l bioreactor working volume. power consum...

This study demonstrates the applicability of pressurized stirred tank bioreactors for oxygen transfer enhancement in aerobic cultivation processes. The specific power input and the reactor pressure was employed as process variable. As model organism Escherichia coli, Arxula adeninivorans, Saccharomyces cerevisiae and Corynebacterium glutamicum were cultivated to high cell densities. By applying...

In this work the Computational Fluid Dynamics simulation of a stirred bioreactor purposely designed for the production of hydrogen from organic wastes fermentation is presented. The bioreactor is a vortex-ingesting, dual impeller, mechanically-agitated vessel equipped with a central draft tube. Due to the geometrical and physical complexity, the selected reactor offers a very challenging benchm...

Streptomyces griseus was cultured in three different bioreactors in a medium containing chitin flakes. When a conventional bioreactor stirred by two sets of Rushton impellers and operated at high speed was used, the yield of streptomycin (3.1mg/l) was the highest observed and occurred at approximately 500 h. Cultivation of S. griseus in a bioreactor stirred at low speed by a U-shaped paddle res...

Streptomyces griseus was cultured in three different bioreactors in a medium containing chitin flakes. When a conventional bioreactor stirred by two sets of Rushton impellers and operated at high speed was used, the yield of streptomycin (3.1 mg/l) was the highest observed and occurred at approximately 500 hours. Cultivation of S. griseus in a bioreactor stirred at low speed by a U-shaped paddl...

in this work, mathematical modeling of microbial(trichosporon sp.) biomass production in a stirred tankbioreactor and in an external airlift bioreactor has beeninvestigated. a model based on a tanks-in-seriesmodel without back-flow has been used to simulate theproduction of single cell protein in the external airliftbioreactor under an unsteady condition and withoutoxygen limitation, utilizing ...