نتایج جستجو برای: steroid neuroprotection

تعداد نتایج: 53442  

Journal: :thrita 0
seyed behnamedin jameie medical basic sciences department, faculty of allied medicine, iran university of medical sciences, tehran, ir iran; medical basic sciences department, faculty of allied medicine, iums, tehran, ir iran. tel: +98-2155306576 mahbobeh mousavi anatomy department, faculty of medicine, tehran university of medical sciences, tehran, ir iran mona farhadi department of microbiology, islamic azad university, karaj, ir iran fereshteh mehraein anatomy department, faculty of medicine, iran university of medical sciences, tehran, ir iran shima ababzadeh anatomy department, qom university of medical sciences, qom, ir iran maryam soleimani department of basic sciences, university of social welfare and rehabilitation sciences, tehran, ir iran

results brdu ihc showed a significant decrease in neurogenesis following tld in both sexes showing more severity in male rats than in female rats. results of nissl staining and mwm also confirmed the brdu findings. regarding sexual dimorphism, our data showed no significant sex differences in the dg area of the hippocampus. conclusions sex-dependent reduction in neurogenesis following tld could...

Journal: :Hong Kong medical journal = Xianggang yi xue za zhi 2012
K F So S W Tang T M C Lee

Key Messages 1. Chronic steroid therapy causes disturbance in cell proliferation of the hippocampus and the subventricular zone. This may be the underlying cause of altered memory and cognitive function. 2. Co-administration of paroxetine (a class of antidepressants) during steroid therapy could counteract the destruction. Modification of the current steroid therapy regimen may be required.

2018
Nicolas Diotel Thierry D. Charlier Christian Lefebvre d'Hellencourt David Couret Vance L. Trudeau Joel C. Nicolau Olivier Meilhac Olivier Kah Elisabeth Pellegrini

Sex steroid hormones are synthesized from cholesterol and exert pleiotropic effects notably in the central nervous system. Pioneering studies from Baulieu and colleagues have suggested that steroids are also locally-synthesized in the brain. Such steroids, called neurosteroids, can rapidly modulate neuronal excitability and functions, brain plasticity, and behavior. Accumulating data obtained o...

2010
Teresa Morales

During motherhood the maternal brain undergoes a collection of adaptive changes including behavioral, neuroendocrine, and autonomic responses related to maternal behavior and milk production. Steroid (estradiol, progesterone, and corticosterone) and peptide hormone (oxytocin and prolactin) levels fluctuate having an impact in areas of the maternal brain inducing structural and functional change...

1996
Pattie S. Green James W. Simpkins

Estradiol (E2) has been shown to exert organizational, neurotrophic, and neuroprotective effects in the CNS. The present study assessed the specificity of the neuroprotective effects of estradiol for the potent 17b-isomer. SK-N-SH cells from a human neuroblastoma cell line, which we have shown to be estrogen-responsive, were cultured at low or high plating density. Then cells were exposed to 17...

2017
Agnieszka Wnuk Małgorzata Kajta

Apoptosis and autophagy are involved in neural development and in the response of the nervous system to a variety of insults. Apoptosis is responsible for cell elimination, whereas autophagy can eliminate the cells or keep them alive, even in conditions lacking trophic factors. Therefore, both processes may function synergistically or antagonistically. Steroid and xenobiotic receptors are regul...

Journal: :CNS & neurological disorders drug targets 2006
A V Kalueff A Minasyan T Keisala M Kuuslahti S Miettinen P Tuohimaa

Vitamin D is a seco-steroid hormone with multiple functions in the nervous system. Physiological brain mechanisms of vitamin D and its receptors include neuroprotection, antiepileptic effects, immunomodulation, possible interplay with several brain neurotransmitter systems and hormones, as well as the regulation of behaviours. Here we review the important role of the vitamin D neuroendocrine sy...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Shui-bing Liu Nan Zhang Yan-yan Guo Rong Zhao Tian-yao Shi Shu-fang Feng Shi-quan Wang Qi Yang Xiao-qiang Li Yu-mei Wu Lan Ma Ying Hou Li-ze Xiong Weiqi Zhang Ming-gao Zhao

17-β-estradiol (E2) is a steroid hormone involved in neuroprotection against excitotoxicity and other forms of brain injury. Through genomic and nongenomic mechanisms, E2 modulates neuronal excitability and signal transmission by regulating NMDA and non-NMDA receptors. However, the mechanisms and identity of the receptors involved remain unclear, even though studies have suggested that estrogen...

Journal: :Annals of the New York Academy of Sciences 2005
Meharvan Singh

Gonadal steroid hormones such as estrogen and progesterone can no longer be considered strictly within the confines of reproductive function, and with respect to their anatomic targets, extrahypothalamic structures within the brain such as the cerebral cortex have revealed themselves to be important targets. As such, it may come as no surprise that the decline in such hormones, which occurs aft...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید