BACKGROUND Pathogenesis and factors for determining progression of alcoholic and non-alcoholic steatosis to steatohepatitis with risk of further progression to liver cirrhosis and cancer are poorly understood. In the present study, we aimed to identify potential molecular signatures for discrimination of steatohepatitis from steatosis. METHODOLOGY AND RESULTS Global microarray gene expression...

BACKGROUND Nonalcoholic steatohepatitis is considered the hepatic manifestation of metabolic syndrome and it is particularly associated to the insulin resistance, hypertension, obesity and abnormalities in lipid and glucose metabolism. OBJECTIVE Considering the importance of obesity and oxidative stress in the pathophysiology of nonalcoholic steatohepatitis, this study aimed to evaluate the p...

fatty liver disease (fld) is the most prevalent form of liver disease worldwide. overnutrition can induce nonalcoholic fatty liver disease (nafld), a spectrum of conditions ranging from simple steatosis [or nonalcoholic fatty liver (nafl)] to nonalcoholic steatohepatitis and cirrhosis. some of the epidemiological and pathological studies have also suggested an association between the presence o...

Drug-induced liver diseases (DILD) are clinico-pathologic patterns of liver injury caused by drugs or other foreign compounds. Steatohepatitis is a rare form of DILD, and drugs account for fewer than 2% of non-alcoholic steatohepatitis (NASH). Drugs known to be capable of inducing steatosis and steatohepatitis can be divided into three broad groups: those that cause steatosis and steatohepatiti...

INTRODUCTION Leptin has been implicated in the pathogenesis of nonalcoholic steatohepatitis. It has also been suggested that adiponectin plays an important role in the transition from fatty liver disease to nonalcoholic steatohepatitis. OBJECTIVE To evaluate whether leptin and adiponectin levels are related to the degree of necroinflammatory activity and fibrosis in patients with nonalcoholic...

In recent years, metabolomics has attracted great scientific attention. The metabolomics methodology might permit a view into transitional phases between healthy liver and nonalcoholic steatohepatitis. Metabolomics can help to analyze the metabolic alterations that play a main role in the progression of nonalcoholic steatohepatitis. Lipid, glucose, amino acid, and bile acid metabolism should be...

Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of triglycerides in the hepatocytes of patients who don’t abuse alcohol. It ranges in severity from simple steatosis (excessive fat accumulation) to steatohepatitis (liver cell injury and inflammation). Nonalcoholic steatohepatitis (NASH) is a subtype of NAFLD in which steatosis coexists with steatohepatitis. NASH can...

BACKGROUND/AIMS Relationship between hepatic antioxidant paraoxonase 1 (PON1) activity, lipid peroxidation and liver injury was investigated in patients with non-alcoholic steatohepatitis. METHODS A total of 23 patients with non-alcoholic steatohepatitis (15 males, 8 females; mean age: 40.30+/-7.67 yrs) and 23 healthy controls (14 males, 9 females; mean age: 39.70+/- 8.78 yrs) were enrolled i...

nonalcoholic steatohepatitis: an expanded clinical entity