Objective(s):Isoprenoid biosynthesis is a key metabolic pathway to produce a wide variety of biomolecules such as cholesterol and carotenoids, which target cell membranes. On the other hand, it has been reported that statins known as inhibitors of isoprenoid biosynthesis and cholesterol lowering agents, may have a direct antimicrobial effect on the some bacteria. The exact action of statins in ...

background: statins (3-hydroxy-3-methylglutarylcoenzyme-a (hmg-coa) reductase inhibitors) decrease cardiovascular mortality and morbidity. this article reviews the role of perioperative statins in non cardiac surgery. methods: a literature review was done on all english published articles till february 2015 about this subject using pubmed. then the reference list of relevant articles was review...

Statins are most effective pharmacologically agents to decrease total plasma cholesterol level by competitive inhibition of HMG-Co A reductase. Apart from the well-known LDL and cholesterol lowering effect, statins have been postulated to exert other beneficial effects also called pleotropic or non-lipid effects. Better understanding of various pleotropic effects of statins has prompted a new s...

objective(s):isoprenoid biosynthesis is a key metabolic pathway to produce a wide variety of biomolecules such as cholesterol and carotenoids, which target cell membranes. on the other hand, it has been reported that statins known as inhibitors of isoprenoid biosynthesis and cholesterol lowering agents, may have a direct antimicrobial effect on the some bacteria. the exact action of statins in ...

statins are most effective pharmacologically agents to decrease total plasma cholesterol level by competitive inhibition of hmg-co a reductase. apart from the well-known ldl and cholesterol lowering effect, statins have been postulated to exert other beneficial effects also called pleotropic or non-lipid effects. better understanding of various pleotropic effects of statins has prompted a new s...

background. this clinical trial evaluated the effect of simvastatin on space re-opening after orthodontic space closure and its effect on the gingival index (gi) and clinical attachment loss (cal). methods. 16 females, 25‒40 years old, with spaces between anterior mandibular teeth due to chronic periodontitis were participated in this study. the patients were randomly divided into control and e...

Chronic obstructive lung disease (COPD) is a chronic multisystem disease with a considerable burden. One of its most common complications is pulmonary artery hypertension (PAH). It has been demonstrated that the development of PAH is correlated with decreased quality of life and survival. Different medications have been proposed for the treatment of PAH, among which one can name statins. Howeve...

background adiponectin is an adipose tissue-derived protein with anti-inflammatory properties. statins are a class of cholesterol-lowering drugs, widely used for treatment of cardiovascular diseases. objectives in the current study, we aimed to assess the effects of simvastatin on serum levels of adiponectin in patients with dyslipidemia, recruited from ghaem hospital, mashhad, iran. materials ...

objective: to review the potential role and specific impact of statin drugs in women with pcos. the evidence for this use of statins in pcos is limited and still under further investigation. materials and methods: a search was conducted using pubmed, dynamed and pubmedhealth databases through october 16, 2016 using the terms polycystic ovary syndrome, pcos, hydroxymethylglutaryl-coa reductase i...

Cancer -can significantly have ruining effects on very high of human beings, social, and economic condition. Gastrointestinal (GI) cancer has been reported as one of the most prevalent cancers and the incidence rates of this disorder is increasing across the world. This review explains practical recommendations for the management and improvement of patients with GI cancer by statins. Statins, a...