background: given the importance of the role of depression in predicting the outcome of cardiovascular disorders, current medications for treating depression, particularly selective serotonin reuptake inhibitors (ssris), are taken into  consideration. this study aimed to systematically review the published findings in the use of ssris and the risk for cardiac events. materials and methods: an i...

selective serotonin reuptake inhibitors (ssris) are reported to be associated with increased bleeding tendency. while findings of recent studies explain a lot about the pathophysiology of this side-effect, there is a general tendency to discontinue ssris as harmful medications. we report two instances of dose-dependent relations between sertraline and bleeding tendency. bleeding diathesis was a...

conclusions these results provide empirical support for conducting a further study on comparing different add-on strategies for treating drug-induced sd. background antidepressant-induced sexual dysfunction (sd) is a common problem, associated with a significant risk of non-adherence. selective serotonin reuptake inhibitors (ssris) are associated with a substantial risk of sd. only 10 % of pati...

this meta-analysis aims to assess the efficacy and safety of ssris and tcas in treatment of pd. a computer-base search was conducted of pubmed, medline, embase, cochrane controlled trails register (cctr) up to december 2011. the random controlled clinic trials about ssris and tcas in pd treatment were collected. statistical analysis was completed using review manager, version 5.0. five clinic c...

This meta-analysis aims to assess the efficacy and safety of SSRIs and TCAs in treatment of PD. A computer-base search was conducted of Pubmed, MEDLINE, EMBASE, Cochrane Controlled Trails Register (CCTR) up to December 2011. The random controlled clinic trials about SSRIs and TCAs in PD treatment were collected. Statistical analysis was completed using Review Manager, version 5.0. Five clinic c...

BACKGROUND SSRIs are widely used in the treatment of mental illness for both children and adults. Studies have found a slightly increased risk of suicidal thoughts and suicide attempts in young people using SSRIs but SSRIs' impact on risk for suicides in youth is not well-established. AIM Is there indication that SSRIs might raise risk for suicide attempts in young people? METHODS We used a...

Antidepressants selectively inhibiting serotonin reuptake (SSRIs) represent a highly effective drug class, and novel therapeutic strategies were proposed to improve SSRIs' drug efficacy. The knowledge of the inhibitory mechanism of FDA approved SSRIs could provide great insights and act as important starting points to discover privileged drug scaffolds with improved efficacy. However, the struc...