نتایج جستجو برای: ssc niche

تعداد نتایج: 26865  

Journal: :iranian journal of veterinary medicine 2013
shiva shafiei parviz tajik hamid ghasemzadeh-nava mansoureh movahedin massoud talebkhan garoussi

background: spermatogonial stem cells (sscs) are infrequentself-renewing cells among the type a spermatogoniawithin the seminiferous tubules and are the basis of spermatogenesisin mammalian testis. an adequate number of sscs is aprimary requirement for the study of their behavior, regulation, andfurther biomanipulation. objectives: in this paper, we studiedthe development of the primary co-cult...

Journal: :Nature Reviews Urology 2018

Journal: :Physiological reviews 2012
Jon M Oatley Ralph L Brinster

This review addresses current understanding of the germline stem cell niche unit in mammalian testes. Spermatogenesis is a classic model of tissue-specific stem cell function relying on self-renewal and differentiation of spermatogonial stem cells (SSCs). These fate decisions are influenced by a niche microenvironment composed of a growth factor milieu that is provided by several testis somatic...

Journal: :Folia histochemica et cytobiologica 2007
Jean-Pierre Dadoune

The spermatogonial stem cells (SSCs) are at the foundation of spermatogenesis. They can self-renew and generate a large number of differentiated germ cells. A balance between SSC renewal and differentiation in the adult testis is essential to maintain normal spermatogenesis and fertility. These two processes are tightly regulated by intrinsic gene expression in the stem cells and extrinsic sign...

2015
Su-Ren Chen Ji-Xin Tang Jin-Mei Cheng Jian Li Cheng Jin Xiao-Yu Li Shou-Long Deng Yan Zhang Xiu-Xia Wang Yi-Xun Liu

Sertoli cells, the primary somatic cell in the seminiferous epithelium, provide the spermatogonial stem cell (SSC) microenvironment (niche) through physical support and the expression of paracrine factors. However, the regulatory mechanisms within the SSC niche, which is primarily controlled by Sertoli cells, remain largely unknown. GATA4 is a Sertoli cell marker, involved in genital ridge init...

2010
Rafael Henrique Nóbrega Caaj Douwe Greebe Henk van de Kant Jan Bogerd Luiz Renato de França Rüdiger W. Schulz

BACKGROUND Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis, and reside within a specific microenvironment in the testes called "niche" which regulates stem cell properties, such as, self-renewal, pluripotency, quiescence and their ability to differentiate. METHODOLOGY/PRINCIPAL FINDINGS Here, we introduce zebrafish as a new model for the study of SSCs in vertebrates. Us...

Journal: :Journal of cell science 2013
Qi-En Yang Dongwon Kim Amy Kaucher Melissa J Oatley Jon M Oatley

Continual spermatogenesis relies on the activities of a tissue-specific stem cell population referred to as spermatogonial stem cells (SSCs). Fate decisions of stem cells are influenced by their niche environments, a major component of which is soluble factors secreted by support cells. At present, the factors that constitute the SSC niche are undefined. We explored the role of chemokine (C-X-C...

Journal: :Animal reproduction 2015
T X Garcia M C Hofmann

Mammalian spermatogenesis is a complex process in which spermatogonial stem cells of the testis (SSCs) develop to ultimately form spermatozoa. In the seminiferous epithelium, SSCs self-renew to maintain the pool of stem cells throughout life, or they differentiate to generate a large number of germ cells. A balance between SSC self-renewal and differentiation is therefore essential to maintain ...

Journal: :avicenna journal of medical biotechnology 0

background: niche cells, regulating spermatogonial stem cells (sscs) fate are believed to have a reciprocal communication with sscs. the present study was conducted to evaluate the effect of ssc elimination on the gene expression of glial cell line-derived neurotrophic factor (gdnf), fibroblast growth factor 2 (fgf2) and kit ligand (kitlg), which are the main growth factors regulating sscs deve...

BACKGROUND: Spermatogonial stem cells (SSCs) are infrequentself-renewing cells among the type A spermatogoniawithin the seminiferous tubules and are the basis of spermatogenesisin mammalian testis. An adequate number of SSCs is aprimary requirement for the study of their behavior, regulation, andfurther biomanipulation. OBJECTIVES: In this paper, we studiedthe development of the primary co-cult...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید