Citation: Haggag YA and Faheem AM (2015) Evaluation of nano spray drying as a method for drying and formulation of therapeutic peptides and proteins. The high sensitivity of peptides and proteins to physicochemical stresses during processing and storage is the major hurdle against its pharmaceutical applications. Peptide-based drug formulations are commonly prepared as solid dosage forms becaus...

Spray-drying was chosen as an appropriately scalable manufacturing method to dry cellulose nanofibril (CNF) suspensions. Spray-drying of two different types of CNF suspensions—nanofibrillated cellulose (NFC) and cellulose nanocrystals (CNC)—was carried out using a laboratory-scale spray dryer. Effects of three spray-drying process parameters on particle morphology and particle size distribution...

Spray drying is a commonly used method of drying a liquid feed through a hot gas. This study aims to obtain the empirical model of the spray drying process of full cream milk using a nozzle atomizer spray dryer, Lab-Plant SD 05 Laboratory Scale Spray Dryer. Inlet air temperature was chosen as the manipulated variable and outlet air temperature was the controlled variable. No disturbance was con...

This work explores the use of both spray drying and d-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process. Spray dried PXM:GLU solid dispersions were prepared and characterised (XRPD, DSC, SEM). Dissolution and triboelectric charging were also conducted. The resu...

inject liquid formulation technology (1), the need arose for a process whereby large quantities of highly polished spherical glass microspheres of known density could be manufactured. The process needed to be inexpensive, scalable, GMP-compliant and capable of sterile manufacture for parenteral drugs. Methods such as emulsion drying, freeze drying and spray-freeze drying were all investigated, ...

Water-insoluble (particulate) β-glucan was isolated from the cell walls of spent brewer’s yeast using a single-step alkaline treatment. To stabilize β-glucan water suspensions, sonication was successfully applied. Th ree diff erent drying methods were used: air-drying, lyophilization and spray-drying. Air-drying and lyophilization caused β-glucan particles agglomeration and changes of their mic...

piroxicam, an anti-inflammatory drug, exhibits poor water solubility and flow properties, poor dissolution and poor wetting. consequently, the aim of this study was to improve the dissolution of piroxicam. microparticles containing piroxicam were produced by spray drying, using isopropyl alcohol and water in the ratio of 40:60 v/v as solvent system, and spray chilling technology by melting the ...

Spray drying is a process widely used to produce fruit juice powders. In powders, it results with the good quality, low water activity, easier transport and storage. The physicochemical properties of powders produced by spray drying depend on the variables of process and/or operating parameters. In the present review, the principle of spray drying was described. In addition, some factors such a...

We find that Mycobacterium smegmatis survives spray drying and retains cell viability in accelerated temperature stress (40 °C) conditions with a success rate that increases with increasing thermal, osmotic, and nutrient-restriction stresses applied to the mycobacterium prior to spray drying. M. smegmatis that are spray dried during log growth phase, where they suffer little or no nutrient-redu...

The aim of this study was to develop a user-friendly model for spray drying that can aid in the development of a pharmaceutical product, by shifting from a trial-and-error towards a quality-by-design approach. To achieve this, a spray dryer model was developed in commercial and open source spreadsheet software. The output of the model was first fitted to the experimental output of a Büchi B-290...