we describe a case of leishmaniasis in a 55-year-old male who presented with weakness, fever and anemia. the patient was born and lived all his life in talaghan, a non-endemic region of kala-azar and there was no history of travel to endemic reigon for leishmania. in primary diagnosis, the patient suspect has been myelofibrosis and then lymphoma and underwent chemotherapy . his general conditio...

Background and Aims: Congenital heart defects (CHD) are the most common type of congenital disability. Copy number variations (CNVs) have been found as one of the genetic etiology of non-syndromic CHD, and researchers have detected several pathogenic CNVs in patients with cardiac defects. Materials and Methods: In the present study, 70 patients with familial (20 patients) and sporadic (50 pati...

human fasciolosis is deemed as an emerging/re-emerging infection, hence making it an important human parasitic disease. in contrast to northern parts of iran, human cases of fasciolosis in southern iran are rare and sporadic. we report a sporadic case of fasciolosis in southern iran (fars province) who presented with prolonged fever. our report could suggest that there might be new foci emergin...

Desmoid tumours (also called deep or aggressive fibromatoses) are potentially life-threatening fibromatous lesions. Hereditary desmoid tumours arise in individuals affected by either familial adenomatous polyposis (FAP) or hereditary desmoid disease (HDD) carrying germline mutations in APC. Most sporadic desmoids carry somatic mutations in CTNNB1. Previous studies identified losses on 5q and 6q...

INTRODUCTION Hypermethylation of the promoter region of the hMLH1 gene is associated with absent expression of MLH1 protein in sporadic colorectal cancers with microsatellite instability (MSI+), and it has been proposed that methylation may be a mechanism of inactivation in Knudson's hypothesis. The incidence of hypermethylation of the hMLH1 promoter in hereditary non-polyposis colorectal cance...

Recently, the breast cancer susceptibility gene BRCA2 has been identified in chromosome 13q, a region that also contains the retinoblastoma gene RB1. To elucidate a possible role of BRCA2 and RB1 in sporadic breast tumorigenesis, allelic imbalance (AI) at 13q loci was examined in 78 primary sporadic breast tumors. AI was found in 52-63% of tumors. Nine tumors showed AI only in the BRCA2 region ...

Adenomatous polyposis coli (APC) gene mutations occur in most sporadic colonic adenomas and carcinomas. Precursor lesions of ulcerative colitis (UC)-associated colon carcinomas, although morphologically similar to sporadic adenomas, may be biologically distinct from them and are, in fact, managed differently. Since sporadic adenomas may also occur in UC, a method of discriminating between these...

This paper investigates the role of neutral winds in the generation of relatively large polarization electric fields across patchy sporadic-E layers, which then map upward to the F region, to create conditions for medium-scale spreadF . The calculations are based on an analytical model that uses the current continuity equation and field-aligned current closures to the F region in order to descr...

background: today, cancer is one of the major health problems worldwide, and the importance of this disease in our country is growing. this cancer is the third cause of death and accounts for the second largest group of non-transmissible chronic diseases. colorectal cancer is the most common gastrointestinal cancer and includes 10%  of deaths from cancer around the world. different genetic and ...