Spondyloarthropathy is a painful arthritic affliction of humans that also occurs in wild mammals. Important questions remain concerning the underlying causes of spondyloarthropathy in mammals, particularly regarding whether it is infectious in origin or driven by genetic predisposition and environmental stressors. Moreover, spondyloarthropathy has negative effects on host fitness, leading to po...

OBJECTIVE Spondyloarthropathy has clearly been documented as not limited in occurrence to humans. Transmammalian in nature, it is of interest to understand the antiquity, and perhaps the origins, of this disorder in animal groups sufficiently represented in the skeletal record. METHODS Fossil and recent skeletons of perissodactylae from North America were systematically examined to determine ...

Arthritic lesions have been frequently diagnosed in the fossil record, with spondyloarthropathy (a type of erosive and pan-mammalian arthritis) being one of the most common types described to date for mammals, though not restricted to this group. Here, we identify spondyloarthropathy in fossil bones from the late Pleistocene in Brazil assignable to a large glyptodont individual. Bone erosions i...

Introduction Spondyloarthritis (SpA) is thought to be very rare in Japan, because possession rate of HLA-B27 in healthy people is 0.4% and it is significantly lower than that of other countries (5%). This makes it difficult for Japanese physicians to diagnose SpA early. Since 10-20% of SpA patients experience symptoms in their childhood, it is very important to distinguish them from other chron...

BACKGROUND The association between spondyloarthropathy and Crohn's disease is well known. A risk for evolution to Crohn's disease has already been shown in the subgroup of patients with spondyloarthropathy associated with chronic gut inflammation. OBJECTIVE To investigate whether the reported polymorphisms in the CARD15 gene, a susceptibility gene for Crohn's disease, are associated with the ...

Background: The association between spondyloarthropathy and Crohn’s disease is well known. A risk for evolution to Crohn’s disease has already been shown in the subgroup of patients with spondyloarthropathy associated with chronic gut inflammation. Objective: To investigate whether the reported polymorphisms in the CARD15 gene, a susceptibility gene for Crohn’s disease, are associated with the ...

BACKGROUND The impact of dialysis dependence on perioperative risks following spinal surgery is not fully understood. The purposes of the present study were to determine the perioperative risks in dialysis-dependent patients treated with spinal surgery and to examine whether the presence of destructive spondyloarthropathy further increases perioperative risks. METHODS We examined abstracted d...

Spondyloarthropathy has been reported among modern individuals of several species of ursid. Prehistoric cervical vertebra of black bear (Ursus americanus) recovered from an archaeological site in northwestern Oregon are fused and distorted, indicating spondyloarthropathy in this species has some time depth. Inventory of this disease among paleozoological remains may reveal unknown details of di...