dendritic cells (dcs) play an important role in induction of cellular immune responses. it seems that dcs that reside in different organs may be distinct in their ability to  induce immune responses. this study was done to address the differences between spleen and liver dcs in induction of immune response and/or tolerance. cd11c+  dcs were separated from the liver and spleen of c57bl/6 mice an...

dendritic cells function as the main cellular population responsible for professional antigen presentation and hence for induction of primary immune responses. although they are present in virtually every tissue, nevertheless their number is usually so low that it makes their isolation for studies very difficult. in this study, we purified dendritic cells from mouse spleen by a three-step enric...

Abstract Introduction Many studies demonstrated that trauma-hemorrhage induces marked alterations in various immune functions. The trauma-hemorrhage-induced immunosuppression is associated with an increased susceptibility to subsequent sepsis, organ failure and mortality. Previous studies demonstrated that trauma-hemorrhage induces immunosuppression in both innate immune systems and adaptive im...

Dendritic cells have been known as a member of strong innate immune cells against infectious organelles. In this study, we evaluated the cytokine expression of splenic dendritic cells in chronic mouse toxoplasmosis by tissue cyst-forming Me49 strain and demonstrated the distribution of lymphoid dendritic cells by fluorescence-activated cell sorter (FACS). Pro-inflammatory cytokines, such as IL-...

objective: the aim of the present study was to investigate the effect of protein and dna components of toxoplasma gondii on maturation of dendritic cells and their efficiency in il-12 production and proliferation of t cells. materials and methods: for dc generation, bone marrow cells were cultured in the presence of gm-csf and il-4 for 5 days. tumor lysate and protein or dna components of toxo...

na

dendritic cells (dcs) are antigen presenting cells with unique capability to take up and process antigens in the peripheral blood and tissues. they subsequently migrate to draining lymph nodes where they present these antigens and stimulate naive t lympho-cytes. during their life cycle, dcs go through two maturation stages and are referred to as immature and mature cells, respectively. while im...

We report two rare examples of Epstein-Barr virus (EBV)-associated inflammatory pseudotumor of the spleen. One patient presented with night sweats, abdominal pain, and weight loss and was found to have a splenic mass on CT scan suspected of lymphoma. The splenic mass in second patient was found incidentally at the time of work up for kidney stones. The pathologic examination of these splenectom...

littoral cell angioma is a splenic vascular tumor of splenic sinus lining cells that is considered benign in general. this report describes a case of littoral cell angioma with no malignant histological features. the lesion is composed of anastomosing vascular channels resembling splenic sinus; they are lined by endothelial cells which show mitotic activity very rare. immunohistochemically, the...

background: dendritic cells (dcs) are potent antigen presenting cells for triggering of the immune reaction post transplantation. these cells are centrally involved in the initiation of t cell-dependent immune responses. objective: to compare the level of dc maturation and function in liver transplant recipients with healthy controls. methods: in this study, twelve peripheral blood samples were...