emerging data suggest that measurement of serum ige to peanut components can be clinically helpful and more accurate than ige to whole peanut to predict peanut allergy. not all studies have used prospective samples, multiple components and oral challenges. currently, there are no data on this topic involving italian children. 32 patients (23 males; median age 9 years) with reported history for ...

Rabbit antisera to the human B-cell-specific antigen complex, p23,30, was used to define further the functional heterogeneity of isolated human lymphocyte subpopulations. Specific depletion of p23,30-bearing cells from Ig-negative cell populations and Ig-negative, E rosette-negative (Null) populations by either complement-mediated lysis or by physical separation on goat antirabbit Fab immunoabs...

Conventional light and electron microscopic methods do not allow a differentiation of Tand B-cells. A clasdficntion of neoplastic lymphatic cells into one of these subpopulations is therefore impossible with common morphological methods. It was not until specific cell funktions, i e. immunoglobulin(IG)-production and the formation of surface-Ig(S-Ig)-receptors, were demonstrable that one could ...

Cadherins are expressed in tissue-restricted patterns and typically mediate homophilic adhesion. Cadherins also mediate lymphocyte adhesion, providing the opportunity for lymphocyte attachment to parenchymal cells. The best characterized example of lymphocyte adhesion to a tissue-specific cell adhesion molecule, as opposed to a vascular endothelial adhesion molecule, is the interaction between ...

The CD28 ligands CD80 and CD86 are expressed on APC, and both provide costimulatory function. However, the reason for the expression of two separate CD28 ligands remains unclear. We have previously shown that blockade of CD80 costimulation by Y100F-Ig, a CTL-associated Ag-4 (CTLA4)-Ig mutant that does not bind CD86, inhibits the development of lung inflammatory immune responses, but does not af...

For any biordered set of idempotents E there is an initial object IG(E), the free idempotent generated semigroup over E, in the category of semigroups generated by a set of idempotents biorder-isomorphic to E. Recent research on IG(E) has focussed on the behaviour of the maximal subgroups. Inspired by an example of Brittenham, Margolis and Meakin, several proofs have been offered that any group...

Background When the specific immunotherapy with house dust mite was done in patients who had allergic diseases, change of specific immunoglobulin(Ig)E and IgG4 is well known. But, it is not known whether there is change for specific IgE and IgG4 during initial build-up phase and there is difference for antibody between rush immunotherapy group and conventional immunotherapy group during mainten...

We report the isolation and characterization of cDNA clones that encode a protein with the same DNA binding specificity as the immunoglobulin heavy chain enhancer binding protein E (muEBP-E). We call the gene encoding this protein Ig/EBP-1. A fusion protein encoded by the cDNA binds specifically to muEBP-E-binding sites (E sites) in both the IgH enhancer and the VH1 promoter. Sequence analysis ...