in the present study, the effect of 5-ht2a receptor blockers in ca1 region of rat hippocampus on spatial learning was assessed in a t-maze, a spatial discrimination task. rats were canulated bilaterally and injected daily vehicle (saline), 5-ht2a-selective antagonist, ketanserin (0.6, 1.2 or 2.4 µg/0.5 µl) and pirenperone (0.1, 0.3, 1.2 or 2.4 µg/0.5 µl) into the cannula 30 minutes before train...

in this study the effects of 5-ht2a receptor blockers in ca1 region of rat hippocampus on spatial learning were assessed in a t-maze, a spatial discrimination task. rats were connulated and bilateral injection of vehicle (saline) and 5-ht2a- selective antagonist, ketanserin (0.6, 1.2 or 2.4 µg/0.5 µl) were injected through the connulae 30 miutes before training each day. results indicated that ...

data on the effects of serotonin reuptake inhibitors on learning and memory processes are not consistent. in the present study, the effects of citalopram, a very potent and completely selective inhibitor of the serotonin reuptake on spatial discrimination in the t-maze and morris water maze, were assessed in mice and/or rats. animals received different doses of citalopram (1, 2, 4, 8 or 16 mg/k...

Data on the effects of serotonin reuptake inhibitors on learning and memory processes are not consistent. In the present study, the effects of citalopram, a very potent and completely selective inhibitor of the serotonin reuptake on spatial discrimination in the T-maze and Morris water maze, were assessed in mice and/or rats. Animals received different doses of citalopram (1, 2, 4, 8 or 16 mg/k...

Discrimination thresholds of spatial frequency and choice reaction times (RT) were measured in three subjects who performed a dual-judgment delayed discrimination task. Two reference gratings were presented side-by-side with a 0-800 msec stimulus onset asynchrony (SOA), which were followed after a 5-sec retention interval by two test gratings. Subjects judged which component changed and which i...

Whereas the spatial discriminative capacities of vision have been mapped out in some detail, virtually nothing is known about tactile spatial sensitivity aside from two-point resolution, point localization, and size discrimination. The purpose here was to assess several spatial discriminative capacities of the distal pad of the index finger: discrimination of spatial misalignment, spatial inter...

The effects of spatial cuing were measured for discrimination between an increment and a decrement on a target's pedestal contrast. Discrimination thresholds measured in the absence of a spatial cue were always higher than corresponding thresholds measured in the presence of a spatial cue, except when pedestal contrast was near zero. Uncued discrimination thresholds rose monotonically with pede...

We used psychometric functions to estimate the joint entropy for space discrimination and spatial frequency discrimination. Space discrimination was taken as discrimination of spatial extent. Seven subjects were tested. Gábor functions comprising unidimensionalsinusoidal gratings (0.4, 2, and 10 cpd) and bidimensionalGaussian envelopes (1°) were used as reference stimuli. The experiment compris...